Replacement of a 500 MHz NMR Console at Florida State University

更换佛罗里达州立大学的 500 MHz NMR 控制台

• 批准号: 9604787
• 负责人: Timothy Logan
• 金额: $ 24.03万
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9604787&HistoricalAwards=false
• 关键词: Replacement; 500; MHz; NMR; Console

Funds are requested to replace an existing Varian VXR 500-S 500 MHz NMR spectrometer console, which is part of the Chemistry Department NMR Facility at Florida State University. Our objective is to replace the existing console with one having three independent radio frequency (rf) channels, waveform generators for each rf channel, and a three-axis pulsed-field gradient accessory. To take advantage of the additional hardware capabilities, we will also purchase a total of three new double- and triple-resonance probes and an off-line Silicon Graphics Indy workstation out-fitted with an external hard-drive and a CD recorder. The 11.7 T Oxford super-conducting magnet, which has very good drift and lineshape specifications, will not be replaced. To optimize the lineshape of the water resonance in biological samples, a new room-temperature shim set will be purchased. This course of action will substantially enhance the overall capabilities of the instrument in a cost-effective manner, while retaining the desirable functional components of the existing system. The replacement spectrometer console will be used for solution studies of ( 1 ) glycoprotein structural biology, (2) protein folding, (3) protein-solvent interactions, (4) RNA structure, (5) structures of RNAprotein complexes, and (6) larger organic molecules.

要求资金替换现有的Varian VXR 500-S 500 MHz NMR光谱仪控制台，该控制器是佛罗里达州立大学化学系NMR设施的一部分。 我们的目标是用具有三个独立射频（RF）通道，每个RF通道的波形发电机和三轴脉冲场梯度附件的波形发电机替换现有控制台。为了利用额外的硬件功能，我们还将购买三个新的双重和三个谐音探针以及一个离线硅图形Indy工作站，该工作站距离装有外部硬盘驱动器和CD录音机。 11.7 T牛津超导磁铁的漂移非常好，线形规格非常好。为了优化生物样品中水共振的线形，将购买新的房间温度垫片。这种行动方案将以具有成本效益的方式可以大大增强仪器的整体功能，同时保留现有系统的理想功能组件。 替换光谱仪控制仪将用于（1）糖蛋白结构生物学，（2）蛋白质折叠，（3）蛋白质 - 溶剂相互作用，（4）RNA结构，（5）RNAProtein复合物的结构，以及（6）较大的有机分子。