MRI: Acquisition of a 500 MHz NMR for Expanding Research and Training in the Wichita Region

该奖项由化学系的主要研究仪器和化学研究仪器项目共同支持。威奇托州立大学将获得一台配备液氮冷却探头的500 MHz核磁共振(核磁共振)光谱仪，以支持詹姆斯·班恩教授及其同事莫里亚·R·贝克、威廉·C·格劳塔斯、凯蒂·米切尔-科赫和吴海凡的研究。该仪器促进了药物设计、癌症治疗、纳米材料和聚合物化学领域的研究。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。与标准的核磁共振探头相比，氮气冷却探头的灵敏度显著提高。这台仪器加强了威奇托州立大学和更广泛地区包括29所农村高校以及当地化工、生物技术和航空工业在内的多个系的各级学生的教育、研究和教学努力。500 MHz核磁共振波谱仪的获奖旨在加强各级研究和教育，特别是在蛋白质、多肽和大分子结构的结构、动力学和相互作用方面，并促进对氟和磷化学位移的理论理解。该仪器使研究重点放在细菌孔形成蛋白的结构和功能、参与肌动蛋白结合的构象动力学和Palladin的Ig结构域对细胞运动的调节，以及设计新的靶向蛋白质-蛋白质界面的限制性多肽。它还帮助设计一类新型的螺环病毒丝氨酸和半胱氨酸蛋白酶的大环抑制剂，并设计和合成先进的聚合物材料。其他研究包括生物分子的磷核磁共振光谱和氟核磁共振研究的计算指导解释，以及新型氰基珊瑚配体金属络合物的结构和电子性质。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs in the Division of Chemistry. Wichita State University is acquiring a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer equipped with a liquid nitrogen cooled probe to support the research of Professor James Bann and colleagues Moriah R. Beck, William C. Groutas, Katie Mitchell-Koch, and Haifan Wu. This instrument facilitates research in the areas of drug design, cancer therapeutics, nanomaterials, and polymer chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The nitrogen-cooled probe provides a significant increase in sensitivity relative to standard NMR probes. This instrument enhances the educational, research, and teaching efforts of students at all levels in many departments at Wichita State University and in the broader region including 29 rural colleges and universities as well as local chemical, biotech, and aviation industries.The award of the 500 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as structure, dynamics and interactions of proteins, peptides, and macromolecular architectures, and advancing a theoretical understanding of fluorine and phosphorous chemical shifts. This instrument enables research focused on the structure-function of bacterial pore forming proteins, conformational dynamics involved in actin binding and regulation of cellular motility by Ig domains of palladin, and designing novel constrained peptides to target protein-protein interfaces. It also assists in the structure-guided design of a novel class of spiro macrocyclic inhibitors of viral serine and cysteine proteases and the design and synthesis of advanced polymeric materials. Other investigations include the computationally guided interpretation of phosphorus NMR spectra and fluorine NMR studies of biomolecules, and the structure and electronic properties of metal complexes of novel cyanoscorpionate ligands.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.