MRI: Acquisition of a 500 MHz NMR for Expanding Research and Training in the Wichita Region

MRI：购买 500 MHz NMR 以扩大威奇托地区的研究和培训

• 批准号: 2216453
• 负责人: James Bann
• 金额: $ 60.63万
• 依托单位: Wichita State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216453&HistoricalAwards=false
• 关键词: MRI; Acquisition; 500; MHz; NMR

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs in the Division of Chemistry. Wichita State University is acquiring a 500 MHz Nuclear Magnetic Resonance (NMR) spectrometer equipped with a liquid nitrogen cooled probe to support the research of Professor James Bann and colleagues Moriah R. Beck, William C. Groutas, Katie Mitchell-Koch, and Haifan Wu. This instrument facilitates research in the areas of drug design, cancer therapeutics, nanomaterials, and polymer chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The nitrogen-cooled probe provides a significant increase in sensitivity relative to standard NMR probes. This instrument enhances the educational, research, and teaching efforts of students at all levels in many departments at Wichita State University and in the broader region including 29 rural colleges and universities as well as local chemical, biotech, and aviation industries.The award of the 500 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as structure, dynamics and interactions of proteins, peptides, and macromolecular architectures, and advancing a theoretical understanding of fluorine and phosphorous chemical shifts. This instrument enables research focused on the structure-function of bacterial pore forming proteins, conformational dynamics involved in actin binding and regulation of cellular motility by Ig domains of palladin, and designing novel constrained peptides to target protein-protein interfaces. It also assists in the structure-guided design of a novel class of spiro macrocyclic inhibitors of viral serine and cysteine proteases and the design and synthesis of advanced polymeric materials. Other investigations include the computationally guided interpretation of phosphorus NMR spectra and fluorine NMR studies of biomolecules, and the structure and electronic properties of metal complexes of novel cyanoscorpionate ligands.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由化学学部的主要研究仪器项目和化学研究仪器项目共同支持。威奇托州立大学正在购买一台配备液氮冷却探头的500兆赫核磁共振（NMR）光谱仪，以支持James Bann教授及其同事Moriah R. Beck, William C. Groutas， Katie Mitchell-Koch和Haifan Wu的研究。该仪器促进了药物设计、癌症治疗、纳米材料和聚合物化学等领域的研究。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。相对于标准核磁共振探针，氮冷却探针的灵敏度显著提高。该工具加强了威奇托州立大学许多系和更广泛地区（包括29所农村学院和大学以及当地化学、生物技术和航空工业）各级学生的教育、研究和教学工作。500兆赫核磁共振光谱仪的奖励旨在加强各级的研究和教育，特别是在蛋白质、肽和大分子结构的结构、动力学和相互作用等领域，并推进对氟和磷化学变化的理论理解。该仪器使研究重点集中在细菌孔形成蛋白的结构-功能，参与肌动蛋白结合的构象动力学和钯蛋白Ig结构域对细胞运动的调节，以及设计针对蛋白质-蛋白质界面的新型约束肽。它还协助设计一种新型病毒丝氨酸和半胱氨酸蛋白酶的螺旋大环抑制剂的结构指导，以及设计和合成先进的聚合物材料。其他研究包括磷核磁共振光谱的计算指导解释和生物分子的氟核磁共振研究，以及新型氰蝎酸配体的金属配合物的结构和电子性质。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。