500 MHz-NMR-Spectrometer

500 MHz 核磁共振波谱仪

• 批准号: 522001443
• 金额: --
• 依托单位: Technische Universität Dresden
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/522001443?language=en
• 关键词: 500; MHz; NMR; Spectrometer

Research at the Faculty of Chemistry and Food Chemistry at TU Dresden deals intensively with the synthesis and analysis of molecules within the fields of bioorganic chemistry, food chemistry, organometallic chemistry, inorganic molecular chemistry and materials chemistry. In addition, the structural elucidation of complex natural products from biomolecular natural product research in Technical Biochemistry plays an increasingly important role. The overall resulting measurement time requirements in routine analysis, which has increased significantly in recent years, as well as for more complex, time-consuming 2D NMR experiments, can no longer be met with the NMR equipment currently available. A modern 500 MHz NMR spectrometer with broadband BBFO probe head (5 mm) is therefore requested, which allows efficient routine measurement with high 13C and simultaneously high 1H sensitivity and also opens up the urgently needed possibility for measurements in routine 2D experiments on samples with normal concentration (> 5 mg/mL), thus significantly relieving the existing 600 MHz system. In addition, the system is supplemented with a 3 mm BBI probe head with high 1H sensitivity, which enables measurement in much smaller sample volumes and thus also allows work with substances in the sub-mg range. Efficient use of the device is ensured by installing an autosampler. The device should have an automatic tuning and matching unit to adjust the probe head to the samples to be examined. This is the only way to facilitate real automatic measurements in the autosampler mode. In addition to the significant increase in sensitivity, which is accompanied by a saving in measurement time, modern shim methods can be used with this device. This increases the resolution of the device, i.e. the measurement quality. The system will be integrated into the newly founded technology platform T-CHE (technology platform "Chemical Analysis") of the faculty and will thereby be made available to a large number of other users of the TU Dresden beyond the listed main users. In automatic routine NMR operation, it is to be used to carry out 1D and 2D experiments on samples with normal conentrations. It is therefore of essential importance for the research performance of the Faculty of Chemistry and Food Chemistry, the other users of the TU Dresden and the entire Dresden Science Area.

德累斯顿工业大学化学与食品化学学院的研究集中在生物有机化学、食品化学、有机金属化学、无机分子化学和材料化学领域的分子合成和分析。此外，从生物分子天然产物研究中对复杂天然产物的结构解析在技术生物化学中起着越来越重要的作用。常规分析的总体测量时间要求近年来显著增加，以及更复杂、耗时的2D NMR实验，目前可用的NMR设备不再能满足。因此，需要具有宽带BBFO探头（5 mm）的现代500 MHz NMR光谱仪，其允许具有高13 C和同时高1H灵敏度的有效常规测量，并且还为常规2D实验中对具有正常浓度（> 5 mg/mL）的样品的测量开辟了迫切需要的可能性，从而显著减轻了现有600 MHz系统的负担。此外，该系统还配备了一个具有高1H灵敏度的3 mm BBI探头，可以在更小的样品体积中进行测量，因此也可以处理亚mg范围的物质。通过安装自动进样器，确保设备的有效使用。该设备应具有自动调谐和匹配单元，以将探头调整到待检查的样品。这是在自动进样器模式下促进真实的自动测量的唯一方法。除了显著提高灵敏度，节省测量时间外，该设备还可以使用现代匀场方法。这提高了设备的分辨率，即测量质量。该系统将被集成到新成立的技术平台T-CHE（技术平台“化学分析”）的教师，从而将提供给德累斯顿工业大学的大量其他用户除了列出的主要用户。在自动化常规核磁共振操作中，用于对正常浓度的样品进行一维和二维实验。因此，它对于化学和食品化学学院，德累斯顿工业大学的其他用户和整个德累斯顿科学区的研究绩效至关重要。