Application of Junction Theory to the Analysis of Sunflower Hybrids

连接理论在向日葵杂交种分析中的应用

• 批准号: 9615335
• 负责人: Loren Rieseberg
• 金额: $ 12万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-15 至 2000-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9615335&HistoricalAwards=false
• 关键词: Application; Junction; Theory; Analysis; Sunflower

9615335 RIESEBERG One of the most exciting recent advances in biology has been the ability to generate detailed genetic maps for almost any plant or animal species. These maps not only are essential for isolating genes of interest, but they also can be used to study important questions in population biology such as how new species are formed. However, mapping data sets are very large and complex, and the current theoretical and analytical tools for exploring them are inadequate. The purpose of this grant is to develop and apply a new theoretical approach called the "method of junctions" to the analysis and interpretation of these complex data sets. Specifically, this method will be applied to mapping data sets derived from hybrids between wild sunflower species of the genus Helianthus. Problems that will be addressed include determining exactly what genetic changes are necessary for new species to be formed and estimating how rapidly this process might take place. Although this proposal will rely on mapping data sets generated for wild sunflower species, the analytical methods developed here should be broadly applicable to any data set that involves genetic mapping data. Some theoretical and practical issues that these methods may affect range from understanding how genes interact with other genes to determining the most effective strategies for moving genes of agronomic importance from wild plants into related cultivated species.

9615335 里瑟堡 生物学最令人兴奋的最新进展之一是能够为几乎任何植物或动物物种生成详细的遗传图谱。这些图谱不仅对于分离感兴趣的基因至关重要，而且还可以用于研究种群生物学中的重要问题，例如新物种是如何形成的。 然而，制图数据集非常庞大和复杂，目前用于探索这些数据集的理论和分析工具不足。 这项资助的目的是开发和应用一种新的理论方法，称为“连接方法”，以分析和解释这些复杂的数据集。 具体而言，这种方法将被应用到映射数据集来自杂交种向日葵属的野生向日葵。 将要解决的问题包括确定新物种形成所需的遗传变化，以及估计这一过程可能发生的速度。 虽然这一建议将依赖于野生向日葵物种生成的映射数据集，这里开发的分析方法应广泛适用于任何数据集，涉及遗传映射数据。 这些方法可能影响的一些理论和实践问题，从理解基因如何与其他基因相互作用，到确定基因间的最大相互作用， 从野生植物中转移重要农艺基因到相关栽培物种的有效策略。