Hybrid Magnetic Field Gradient Enhanced Colloidal Separations

建议编号：CTS-9618635建议类型：SGER首席研究员：Arijit Bose从属关系：罗德岛大学研究人员建议使用磁场通过一种新型的基于亲和力的分离器移动功能化的磁性粒子。这项工作的目标是允许这些功能化的磁性颗粒与目标分子(或细胞)接触，而不会产生明显的持续影响。这项研究的新奇之处在于，反应堆的设计包括可调磁场，允许径向和/或轴向的磁梯度。使用功能化的磁性/超顺磁性粒子来去除特定的分子/细胞等是至关重要的。例如，如果癌细胞可以从骨髓中移除，患者自己的骨髓就可以重新移植(在化疗后)，从而消除了移植的需要。有几家小型初创公司已经成功地制造出功能化的磁性颗粒，PI将使用其中一家公司(BioQuest)的颗粒。但简单地使用机械搅拌使细胞与功能化颗粒接触会导致剪切诱导的细胞死亡。因此，PI正在攻击的问题是将扩散和对流传输的化学工程基础应用于分离器设计中的一个新问题的理想案例。新奇之处在于问题和分离器设计。如果成功，该方案可能会通过使用连续系统实现更大的吞吐量，并另外保持细胞活力，从而使细胞分离领域发生革命性变化。这确实是一个高回报的项目。同样令人兴奋的是，分离器原型可以用SGER的最小投资来建造。

Proposal No: CTS-9618635 Proposal Type: SGER Principal Investigator: Arijit Bose Affiliation: University of Rhode Island The investigator proposes to use magnetic fields to move functionalized magnetic particles through a novel affinity based separator. The objective of the work is to allow these functionalized magnetic particles to contact target molecules (or cells) without the significant sustained. The novelty of the research is the reactor design involving tunable magnetic fields allowing magnetic gradients in the radial and /or axial directions. The use of functionalized magnetic/superparamagnetic particles to remove specific molecules/cells etc. is of vital importance. For example, if cancerous cells can be removed from bone marrow, the patient's own bone marrow can be re-implanted (after chemotherpy) thereby eliminating the need for a transplant. There are several small startup companies that have succeeded in making functionalized magnetic particles and the PI will use the particles from one of them (Bioquest). But simply using mechanical agitation to contact cells with the functionalized particles leads to shear induced cell death. Hence the problem the PI is attacking is an ideal case of applying chemical engineering fundamentals of diffusion and convective transport to a novel problem in separator design. The novelty is the problem and the separator design . If successful, this scheme could revolutionize the field of cell separations, by allowing greater throughput by using a continuous system, and additionally sustaining cell viability. This is truly a high payoff project. What is also exciting is that the seperator prototype can be built with the minimal investment of the SGER.