Analysis of the role of the B cell inhibitory receptor Siglec-G in autoimmunity and infection models

B细胞抑制性受体Siglec-G在自身免疫和感染模型中的作用分析

• 批准号: 109957018
• 负责人: Professor Dr. Lars Nitschke
• 金额: --
• 依托单位: Department Biologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/109957018?language=en
• 关键词: Analysis; role; cell; inhibitory; receptor

Siglec proteins are a family of inhibitory receptors on immune cells. We recently characterized Siglec-G as a new member of this family. Siglec-G is expressed on B lymphocytes and has a specific role as inhibitory receptor on the B1 cell subset in the mouse. This was found in Siglec- G-deficient mice with have a large expansion of B1 cells and increased B1 cell Ca2+ responses. This proposal addresses the role of Siglec-G in systemic autoimmunity and anti-bacterial immunoglobulin responses which will be studied during a research visit in a lab at Cambridge University.

Siglec蛋白是免疫细胞上的抑制性受体家族。我们最近将Siglec-G描述为该家族的一个新成员。Siglec-G在小鼠B淋巴细胞上表达，作为小鼠B1细胞亚群的抑制性受体具有特异性作用。这是在Siglec-G缺陷小鼠的B1细胞大量扩张和B1细胞钙离子反应增强的情况下发现的。这项提案涉及Siglec-G在系统自身免疫和抗细菌免疫球蛋白反应中的作用，这将在剑桥大学实验室的一次研究访问中进行研究。