A Nonlinear Dynamical Technique for Improving the Function of the Human Postural Control System

改善人体姿势控制系统功能的非线性动力学技术

• 批准号: 9634024
• 负责人: James Collins
• 金额: --
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-15 至 2000-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9634024&HistoricalAwards=false
• 关键词: Nonlinear; Dynamical; Technique; Improving; Function

9634024 Collins The objective of this project, which is a renewal proposal of a prior NSF award, is to develop a noise-based technique which can be used to lower the detection thresholds of the proprioceptive system and thereby improve the performance of the human postural control system. Upright stance in humans is regulated by a complex control system that involves a number of different sensory mechanisms, including the proprioceptive system. Aperiodic stochastic resonance (ASR) is a phenomenon wherein the response of a nonlinear system to a subthreshold aperiodic input signal is optimized by the presence of a particular level of noise. ASR has been demonstrated in a simple neuronal model and in cutaneous sensory neurons. This work suggests that it should be possible to introduce noise artificially into a neurophysiological sensory system (e.g., the proprioceptive system) in order to improve its ability to detect arbitrary subthreshold signals. To date, however, bioengineering applications have not been explored. The specific objectives of this study are 1) to develop a physiologically-realistic neuronal model as a test-bed for bioengineering applications of ASR; 2) to demonstrate that the detection thresholds of the proprioceptive system are changed with the addition of input noise; and 3) to demonstrate that noise-induced changes to the proprioceptive detection thresholds at the ankle affect the postural control system. This work could result in the development of an inexpensive technique for improving the performance of the human postural control system. Such a technique could have important ramifications for individuals with elevated proprioceptive thresholds, such as older adults and patients with neural disorders, who may be predisposed to falls. Thus, the results of this project could eventually serve to reduce the incidence, cost, and health risks of falling. ***

9634024 Collins该项目的目标是对先前NSF奖的续签建议，是开发基于噪声的技术，可用于降低本体感受系统的检测阈值，从而提高人类姿势控制系统的性能。人类的直立姿态受一个复杂的控制系统的调节，该系统涉及多种不同的感觉机制，包括本体感受系统。上的随机共振（ASR）是一种现象，其中非线性系统对亚阈值的急诊输入信号的响应通过特定噪声水平的存在优化。 ASR已在简单的神经元模型和皮肤感觉神经元中证明。这项工作表明，应该可以将噪声人为地引入神经生理感觉系统（例如，本体感受系统），以提高其检测任意子阈值信号的能力。但是，迄今为止，尚未探讨生物工程应用程序。这项研究的具体目标是1）开发一种生理现实的神经元模型，作为ASR生物工程应用的测试床； 2）证明，通过添加输入噪声，将更改本体感受系统的检测阈值； 3）证明脚踝处的本体感受检测阈值会影响姿势控制系统。这项工作可能导致开发一种廉价的技术，以改善人类姿势控制系统的性能。这种技术可能会对具有升高的本体感受阈值的个体（例如老年人和神经疾病患者）具有重要的后果，这些患者可能会倾向于跌倒。因此，该项目的结果最终可以减少跌倒的发病率，成本和健康风险。 ***