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Disease Ecology and its Role in Shaping Life History

Disease Ecology and its Role in Shaping Life History
疾病生态学及其在塑造生命史中的作用
批准号:
9816645
负责人:
James Collins
金额:
$22.5万
依托单位:
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-03-15 至 2002-02-28

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英文摘要
ABSTRACT The proposed research investigates how disease emerges in populations of salamanders in Arizona, is transmitted among individuals in populations, spreads across populations in a region, and finally, via natural selection, may alter salamander life history. Three hypotheses will be tested. Within a habitat, animals, soil, or water harbor viruses and environmental changes initiate infections by stimulating pathogen growth or weakening host salamanders. Alternatively, salamanders in a habitat are susceptible and disease is introduced from elsewhere. Experiments and field observations will evaluate the roles of salamanders, invertebrates, cows, birds, or humans as possible reservoirs of disease or vectors dispersing virus. Finally, disease selects against cannibalism, accounting for regional variation in salamander life history. The virus-vector-tiger salamander system is ideal for testing models in disease ecology. Arizona populations are well-studied, the principal viral pathogen is known, infections are frequent, and all habitats for one endangered subspecies where disease is common can be sampled. In the last fifteen years some species of amphibians have declined steadily, even to extinction, and pathogens are a possible cause. This research will advance our understanding of pathogens as a factor in amphibian declines; a key example of the general loss of biodiversity. Proposed experiments and observations incorporate experts in ecology, evolution, pathology, virology, and molecular genetics. Vertically-integrated field and laboratory experiments will untangle complex interactions from molecular genetics to population biology to test general models of disease ecology.
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Workshop to Revise the Liberal Art of Science
  • 批准号:
    1817808
  • 项目类别:
    Standard Grant
  • 资助金额:
    $0.55万
  • 财政年份:
    2018
  • 负责人:
    James Collins
  • 依托单位:
DISSERTATION RESEARCH: Iron availability and dynamics of an emerging infectious disease: Can a micronutrient cause macro-level outcomes?
  • 批准号:
    1209178
  • 项目类别:
    Standard Grant
  • 资助金额:
    $1.5万
  • 财政年份:
    2012
  • 负责人:
    James Collins
  • 依托单位:
UMEB: Educating a New Generation of Environmental Professionals
  • 批准号:
    0305279
  • 项目类别:
    Standard Grant
  • 资助金额:
    $6.94万
  • 财政年份:
    2003
  • 负责人:
    James Collins
  • 依托单位:
DISSERTATION RESEARCH: The Evolution of Parasite Virulence: Experimental Tests using a Lethal Salamander Virus
  • 批准号:
    0309099
  • 项目类别:
    Standard Grant
  • 资助金额:
    $1.16万
  • 财政年份:
    2003
  • 负责人:
    James Collins
  • 依托单位:
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