Bimetallic Cooperativity in Homogeneous Catalysis

该奖项在无机，生物无机和有机化学 计划继续支持研究均相催化博士。 乔治路易斯安那州化学系的斯坦利 大学 这项工作的目标是了解合作， 通过研究一种具有活性且 选择性加氢。 该双阳离子复合物含有 双核四膦配体。 结合位点的性质将 在分子建模的帮助下阐明，除了 实验方法，包括动力学、光谱和同位素 标签研究。 研究结果将用于改进 催化剂的区域选择性和对映选择性。 在这一阶段之后， 研究，将尝试扩大合作， 其他催化反应，例如硅氢加成，硅烷基甲酰基化， 氢氰化以及与烯烃和炔的C-C键偶联反应。 在某些催化体系中，两种不同金属的协同作用 已经提出，位点不仅在促进反应方面有效， 速度更快，而且是针对特定形状的。 本工程 将确定催化剂设计中的协同性潜力。 的 控制反应速率和产物的能力在许多情况下非常重要 化学制造领域，如药品生产， 聚合物和精细化学品。

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program continues support for research on homogeneous catalysis by Dr. George G. Stanley of the Chemistry Department, Louisiana State University. The goal of the work is to understand cooperativity in bimetallic catalysis by studying a dirhodium complex that is active and selective in hydroformylation. This dicationic complex contains a binucleating tetraphosphine ligand. The nature of the binding site will be elucidated with the aid of molecular modeling, in addition to experimental approaches, including kinetic, spectroscopic and isotopic labeling studies. The results will be used to make improvements in the regio- and enantioselectivty of the catalyst. After this stage of the research, attempts will be made to extend bimetallic cooperativity to other catalytic reactions, such as hydrosilylation, silylformylation, hydrocyanation, and C-C bond coupling reactions with alkenes and alkynes. In some catalytic systems, the cooperative action of two different metal sites has been suggested to be effective in promoting reactions not only more quickly, but also shape-specifically. In this project, the potential of cooperativity in catalyst design will be determined. The ability to control reaction rates and products is very important in many areas of chemical manufacturing, such as production of pharmaceuticals, polymers, and fine chemicals.