Applications of Filament Dynamics to Physics, Biology, and Engineering

细丝动力学在物理学、生物学和工程中的应用

• 批准号: 9704486
• 负责人: Isaac Klapper
• 金额: $ 6.99万
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9704486&HistoricalAwards=false
• 关键词: Applications; Filament; Dynamics; Physics; Biology

Klapper 9704486 Motivated by a range of problems and, in particular, the observed iterated, stretching and writhing motions of certain bacterial filaments, the investigator and his collaborator Michael Tabor at the University of Arizona develop new techniques to study the linear and nonlinear stability of the time-dependent equations governing elastic filament dynamics (the Kirchhoff equations) and, in parallel, computational approaches to provide efficient numerical simulations. Overall, the investigators develop (i) new analytic techniques to study both the linear and nonlinear stability of elastic filaments, (ii) quantitative models of writhing instabilities and buckling phenomena in mechanical filaments, (iii) mathematical models of self-assembling bacterial fibers, lipid bi-layer roll-up and various aspects of DNA dynamics, (iv) efficient and flexible algorithms to simulate the described physical and biological processes and to test the validity of the (continuum) models, (v) discrete elastic models for simulating DNA conformations, (vi) theoretical and numerical models of solar magnetic fields with twist. A host of practical problems in the biological, physical and engineering sciences involve filamentary structures on scales varying from the microscopic to the macroscopic. These include, in progression of scales: molecular structures including DNA and lipid tubules and helices, bacterial fibers, vorticity filaments, ropes and cables, braided magnetic flux tubes as seen in solar flares, etc. The motion of these structures has a crucial impact on their structure and function. The investigators develop general computational methods to model these filaments and their uses, including the structure and function of DNA, and the self-assembly of advanced biomaterials.

克拉珀9704486 受到一系列问题的启发，特别是观察到的某些细菌细丝的迭代，拉伸和扭动运动，研究人员和他的合作者亚利桑那大学的Michael塔博尔开发了新技术来研究控制弹性细丝动力学的时间依赖方程的线性和非线性稳定性（基尔霍夫方程），并在并行计算方法，以提供有效的数值模拟。 总的来说，研究人员开发（i）新的分析技术来研究弹性细丝的线性和非线性稳定性，（ii）机械细丝中扭曲不稳定性和屈曲现象的定量模型，（iii）自组装细菌纤维，脂质双层卷起和DNA动力学各个方面的数学模型，（iv）有效和灵活的算法，以模拟所描述的物理和生物过程，并测试所描述的物理和生物过程的有效性。（连续体）模型，（v）用于模拟DNA构象的离散弹性模型，（vi）具有扭曲的太阳磁场的理论和数值模型。 生物、物理和工程科学中的许多实际问题涉及从微观到宏观尺度上的结构。 这些包括，在规模的进展：分子结构，包括DNA和脂质小管和螺旋，细菌纤维，涡丝，绳索和电缆，编织磁通管在太阳耀斑等，这些结构的运动对它们的结构和功能有着至关重要的影响。 研究人员开发了通用的计算方法来模拟这些细丝及其用途，包括DNA的结构和功能，以及先进生物材料的自组装。