Directed migration of oligodendroglial progenitor cells: role of NG2 and fyn kinase

少突胶质祖细胞的定向迁移：NG2 和 fyn 激酶的作用

• 批准号: 113950053
• 负责人: Professorin Dr. Jacqueline Trotter, Ph.D.
• 金额: --
• 依托单位: Institut für Entwicklungsbiologie und Neurobiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/113950053?language=en
• 关键词: Directed; migration; oligodendroglial; progenitor; cells

Migration of oligodendrocyte progenitor cells (OPC) to reach their target axons is still poorly understood. OPC express the proteoglycan NG2 which plays a role in migration in several cell types. The aim of the project is to analyse the molecular pathways by which NG2 influences migration in OPC and especially to determine whether it plays a role in the direction of migration by establishing a polarised state of the cell. The non-receptor tyrosine kinase fyn influences process outgrowth by OPC, important for migration. Links between fyn and NG2 signalling pathways will be examined and interactions between NG2 and integrins, known activators of fyn kinase in OPC will also be analysed.

少突胶质祖细胞（OPC）迁移到其靶轴突仍然知之甚少。OPC表达蛋白聚糖NG2，其在几种细胞类型中的迁移中起作用。该项目的目的是分析NG2影响OPC迁移的分子途径，特别是确定它是否通过建立细胞的极化状态在迁移方向上发挥作用。非受体酪氨酸激酶fyn通过OPC影响过程生长，这对迁移很重要。将检查fyn和NG2信号通路之间的联系，并分析NG2和整联蛋白（OPC中fyn激酶的已知激活剂）之间的相互作用。