Expression and Function of the LTP-Associated Gene During Learning

LTP相关基因在学习过程中的表达和功能

• 批准号: 9706664
• 负责人: Sandra Pena de Ortiz
• 金额: $ 3.5万
• 依托单位: University of Puerto Rico-Rio Piedras
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-15 至 1998-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9706664&HistoricalAwards=false
• 关键词: Expression; Function; LTP; Associated; Gene

9706664 Pena de Ortiz The formation of long term memory is though to involve the modification of cells within the brain. Such modification is believed to depend on changes in the regulation of gene function in those cells. This project uses the techniques of molecular biology to investigate changes in gene expression during the acquisition of memory in one important part of the brain termed the hippocampus. The project documents the time course of changes in gene expression that occur as memories are acquired. Experiments then proceed to identify the DNA sequences of genes linked to learning-induced changes, and thereafter the functions of the products of those genes. The results of this project will add significantly to the understanding of how the brain stores information

9706664佩纳德奥尔蒂斯 长期记忆的形成被认为涉及大脑内细胞的修改。这种修饰被认为取决于这些细胞中基因功能调节的变化。这个项目使用分子生物学技术来研究在大脑的一个重要部分--海马体--中获得记忆过程中基因表达的变化。该项目记录了在获得记忆时发生的基因表达变化的时间过程。然后进行实验，以确定与学习引起的变化有关的基因的DNA序列，以及这些基因产物的功能。这个项目的结果将大大增加对大脑如何存储信息的理解