Asymmetric Catalysis of Carbon-Carbon Bond-Forming Reactions

碳-碳键形成反应的不对称催化

• 批准号: 9706766
• 负责人: Thaliyil RajanBabu
• 金额: $ 32.6万
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9706766&HistoricalAwards=false
• 关键词: Asymmetric; Catalysis; Carbon; Bond; Forming

The focus of this research is the development of enantioselective carbon-carbon bond forming reactions involving Ni-catalyzed hydrocyanation, hydroformylation and hydrovinylation. Systematic steric and electronic ligand tuning will lead to the development of improved catalysts for the production of compounds compounds with interesting biological properties as well as polymer intermediates. With this new award, the Synthetic Organic program is supporting the research of Dr. T.V. Rajanbabu of the Department of Chemistry at Ohio State University. Professor RajanBabu will focus his work on developing catalytic carbon-carbon bond making reactions. Hydrocyanation, hydroformylation and hydrvinylation processes will be examined. The methodology allows for the catalytic, stereoselective incorporation of inexpensive carbon and hydrogen sources into the production of important chemical intermediates.

本研究的重点是开发对映选择性的 涉及Ni催化的碳-碳键形成反应 氢氰化、氢化和氢化乙烯化。 系统立体 和电子配体调谐将导致改进的 用于生产具有感兴趣的化合物的催化剂 生物学性质以及聚合物中间体。有了这个新 奖，合成有机计划是支持博士的研究。 俄亥俄州州立大学化学系的T. V. Rajanbabu说。 RajanBabu教授将专注于开发催化剂 碳-碳键形成反应。 氢氰化，氢化 和加氢乙烯化过程将被检查。 该方法允许 用于廉价碳的催化、立体选择性结合， 和氢的来源， 中间体的