Catalytic Methods for C-C Bond-Forming Reactions

C-C 键形成反应的催化方法

• 批准号: 0308378
• 负责人: Thaliyil RajanBabu
• 金额: $ 39万
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-15 至 2007-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0308378&HistoricalAwards=false
• 关键词: Catalytic; Methods; Bond; Forming; Reactions

The focus of this research involves the development of catalytic, stereoselective carbon-carbon bond forming reactions. New ligands for asymmetric catalysis will be synthesized and hydrovinylation of prototypical vinylarenes, dienes and strained olefins will be carried out. Further, heterodimerizations including dienes and strained olefins will be probed with the goal of solving the problem of exocyclic stereochemistry and applications of palladium-catalyzed, X-Y-mediated ([X-Y] = [Si-Sn], [B-Sn], [Sn-Sn]) cyclization of diynes, alleneynes and allenylaldehydes will be provided for the stereoselective synthesis of carbocyclic and heterocyclic compounds.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Thaliyil V. RajanBabu in the Department of Chemistry at the Ohio State University. Professor RajanBabu will focus on developing methodology for using abundantly available carbon sources in the catalytic processes for the synthesis of chemical intermediates. The hydrovinylation of commercially relevant vinylarenes as well as dienes and strained olefins will be studied. The utility of the approach will be showcased by the preparation of synthesis of several biologically active targets. The project has broader impacts for the pharmaceutical and agricultural industries and provides an excellent climate for the training of graduate students.

本研究的重点涉及催化的，立体选择性的碳-碳键形成反应的发展。 合成新的不对称催化配体，并进行典型的乙烯基芳烃、二烯烃和张力烯烃的加氢乙烯化反应。 此外，包括二烯和应变烯烃的杂二聚反应将被探索，目标是解决环外立体化学问题和钯催化的X-Y介导的（[X-Y] = [Si-Sn]，[B-Sn]，[Sn-Sn]）二炔，联炔和联烯醛的环化反应将为碳环和杂环化合物的立体选择性合成提供条件。有机和高分子化学计划正在支持俄亥俄州州立大学化学系的Thaliyil V. RajanBabu博士的研究。 RajanBabu教授将专注于开发在化学中间体合成的催化过程中使用丰富可用碳源的方法。将研究商业上相关的乙烯基芳烃以及二烯和应变烯烃的加氢乙烯化。 该方法的实用性将通过几种生物活性靶标的合成来展示。 该项目对制药业和农业产生了更广泛的影响，并为研究生的培训提供了良好的环境。