Asymmetric Catalysis of Carbon-Carbon Bond-Forming Reactions

这项研究的重点是双重的。首先，将开发简单烯烃（如乙烯和丙烯）对映选择性掺入前手性分子的方法。其次，将开发分子内偶联- - -二烯和- - -二烯的新策略，用于合成碳环和杂环化合物。有了这个更新奖，有机和大分子化学项目支持俄亥俄州立大学化学系的Thaliyil V. RajanBabu博士的研究。RajanBabu教授将专注于开发基于中性分子催化活化的高选择性碳-碳键形成反应。该研究对制药、农业和材料科学具有潜在的广泛影响，并为研究生的培养提供了良好的环境。

The foci of this research are twofold. First, methodology will be developed for the enantioselective incorporation of simple olefins such as ethylene and propylene into prochiral molecules. Second, new strategies will be developed for intramolecular coupling of alpha, omega-dienes and alpha, omega-diynes for the synthesis of carbocyclic and heterocyclic compounds.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Thaliyil V. RajanBabu of the Department of Chemistry at Ohio State University. Professor RajanBabu will focus his work on developing highly selective carbon-carbon bond forming reactions based on catalytic activation of neutral molecules. The research has potential broader impacts for pharmaceutical, agricultural and materials science and provides an excellent milieu for the training of graduate students.