Asymmetric Catalysis of Carbon-Carbon Bond-Forming Reactions

碳-碳键形成反应的不对称催化

• 批准号: 0079948
• 负责人: Thaliyil RajanBabu
• 金额: $ 32.6万
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2004-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0079948&HistoricalAwards=false
• 关键词: Asymmetric; Catalysis; Carbon; Bond; Forming

The foci of this research are twofold. First, methodology will be developed for the enantioselective incorporation of simple olefins such as ethylene and propylene into prochiral molecules. Second, new strategies will be developed for intramolecular coupling of alpha, omega-dienes and alpha, omega-diynes for the synthesis of carbocyclic and heterocyclic compounds.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Thaliyil V. RajanBabu of the Department of Chemistry at Ohio State University. Professor RajanBabu will focus his work on developing highly selective carbon-carbon bond forming reactions based on catalytic activation of neutral molecules. The research has potential broader impacts for pharmaceutical, agricultural and materials science and provides an excellent milieu for the training of graduate students.

这项研究的重点是双重的。 首先，将开发用于将简单烯烃如乙烯和丙烯对映选择性并入前手性分子的方法。 第二，将开发用于合成碳环和杂环化合物的α，ω-二烯和α，ω-二炔的分子内偶联的新策略。有了这个更新奖项，有机和大分子化学计划将支持俄亥俄州州立大学化学系的Thaliyil V. RajanBabu博士的研究。 RajanBabu教授将专注于开发基于中性分子催化活化的高选择性碳-碳键形成反应。 该研究对制药，农业和材料科学具有潜在的更广泛的影响，并为研究生的培养提供了良好的环境。