Fundamental Separations Studies of Pressure-Induced Perturbations in Complexation

克莉丝汀E.埃文斯是由分析和表面化学 研究压力作为变量对约束力的影响的程序 β-环糊精复合物的常数，并确定 这类络合物的色谱保留压力和选择性。 这种主客体相互作用形成了液相色谱的基础。 和电泳分离困难的位置异构体， 对映体 液相色谱，核磁 共振和荧光测量将用于检查 压力效应。 毛细管电泳在高压下将 探索并用于测量的压力依赖性， 这些复杂的反应。 这项工作探讨了使用压力作为化学变量， 涉及β-环糊精的复合物的分离。 更好的 了解这些络合物的溶液化学， 它们的分离方法有可能产生积极影响， 纯药物和其它化合物的制备 需要高的化学纯度和结构相同性。

Christine E. Evans is supported by the Analytical and Surface Chemistry Program to study the effects of pressure as a variable on the binding constants of beta-cyclodextrin complexes and to determine the effects of pressure on chromatographic retention and selectivity of such complexes. Such host-guest interactions form the basis for liquid chromatographic and electrophoretic separations of difficult positional isomers and enantiometric species. Liquid chromatographic, nuclear magnetic resonance, and fluorescence measurements will be used to examine the pressure effects. Capillary electrophoresis at high pressure will be explored and also used in the measurement of the pressure dependence of these complexation reactions. This work explores the use of pressure as a variable in the chemistry and separation of complexes involving beta-cyclodextrin. A better understanding of the solution chemistry of these complexes and improved methods for their separation has the potential to impact positively on the preparation of pure pharmaceuticals and other compounds which are needed in a high state of chemical purity and structure sameness.