Adsorbent Materials for Liquid Phase Separations

用于液相分离的吸附材料

• 批准号: 2305066
• 负责人: Luis Colon
• 金额: $ 45.71万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2305066&HistoricalAwards=false
• 关键词: Adsorbent; Materials; Liquid; Phase; Separations

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Professor Luis A. Colón and his research group at SUNY Buffalo are developing innovative organo-silica adsorptive materials. These materials are an essential component in separation methodology used in chemical analysis, which in turn is central to chemical, biological, environmental, pharmaceutical, and other related sciences. The materials are based on silica structures and designed to have useful physicochemical characteristics with the goal of improving the currently used separation media, with consideration in the chemical analysis of contaminants. The research approach is targeting a flexible platform on which different separation materials could be synthesized, bringing new possibilities for their use in specific practical applications. The research activities will engage graduate and undergraduate students, including members of traditionally underrepresented groups, providing advanced training and skills in chemical analysis necessary for the modern-day workforce in the academic, pharmaceutical, and industrial chemical sectors. The research project is focused on the synthesis and the physicochemical characterization of organo-silica adsorbent materials. The adsorbent will be synthesized on core magnetic nanoparticles and core silica particles to be used in magnetic solid phase extraction (SPE) and in liquid chromatography (LC). The adsorbent material will consist of a silica-hybrid that will have a characteristic fibrous/dendritic-type structure, while containing azide-chemical functionalities at the surface, serving as a platform to react with chemical entities that will alter the surface chemical composition of the material via “click” chemistry (copper-catalyzed azide-alkyne cyclocondensation). The organo-silica surface will be modified with chemical functionalities (e.g., fluorocarbons, ion exchangers, and polar moieties) that will provide a set of different mixed-mode interactions in liquid phase separations. Through a systematic evaluation, using well-established techniques (e.g., infrared spectroscopy, elemental analysis, gas adsorption analysis, and scanning electron microscopy) the physicochemical properties of the materials will be established. LC and SPE will be used to examine the chromatographic and adsorptive performance of the newly synthesized materials, which will include the use of standard protocols to assess the selectivity and stability of the materials. The project holds promise for advancing knowledge in the field of adsorbent materials for use in separation methods. The new materials will be used in chemical analysis, for example, in the analysis of pollutants and pharmaceutical compounds.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学划分的化学测量和成像计划的支持下，路易斯·A·科隆教授及其在纽约州立大学的研究小组正在开发创新的有机硅吸附材料。这些材料是化学分析中使用的分离方法中的重要组成部分，进而对化学，生物学，环境，药物和其他相关科学而言至关重要。材料基于二氧化硅结构，旨在具有有用的物理特性，目的是改善当前使用的分离介质，并考虑到污染物的化学分析。研究方法是针对一个灵活的平台，可以在该平台上综合不同的分离材料，从而为它们在特定的实际应用中使用带来了新的可能性。研究活动将吸引研究生和本科生，包括传统代表性不足的群体的成员，为学术，制药和工业化学领域的现代劳动力所必需的化学分析提供高级培训和技能。该研究项目的重点是有机硅吸附剂材料的合成和物理表征。吸附剂将在核心磁性纳米颗粒和核心二氧化硅颗粒上合成，用于磁性固相（SPE）（SPE）和液相色谱（LC）。吸附剂的材料将由二氧化硅混合物组成，该硅杂交将具有特征性的纤维/树突状结构，同时包含表面上的叠氮化物化学功能，它是与化学实体反应的平台，该平台将通过“单击”化学（铜）化学（铜）化学（铜）化学作用（铜）化学（铜）化学（Copper-Catalys）。有机硅表面将通过化学功能（例如，氟化合物，离子交换器和极性部分）进行修饰，这些功能将在液相分离中提供一组不同的混合模式相互作用。通过系统的评估，使用良好的技术（例如红外光谱，元素分析，气体吸附分析和扫描电子显微镜）将建立材料的物理特性。 LC和SPE将用于检查新合成材料的色谱和吸附性能，其中包括使用标准方案来评估材料的选择性和稳定性。该项目有望在吸附物材料领域中推进用于分离方法的知识。新材料将用于化学分析，例如，在污染物和药物化合物的分析中。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响评估标准，被视为通过评估来获得珍贵的支持。