Adsorbent Materials for Liquid Phase Separations

在化学系的化学测量和成像项目的支持下，路易斯·A。科隆和他在纽约州立大学布法罗的研究小组正在开发创新的有机硅吸附材料。这些材料是化学分析中使用的分离方法的重要组成部分，而化学分析又是化学、生物、环境、制药和其他相关科学的核心。这些材料基于二氧化硅结构，设计具有有用的物理化学特性，目的是改进目前使用的分离介质，并考虑污染物的化学分析。该研究方法的目标是一个灵活的平台，在这个平台上可以合成不同的分离材料，为它们在特定的实际应用中的使用带来新的可能性。研究活动将吸引研究生和本科生，包括传统上代表性不足的群体的成员，提供学术、制药和工业化学领域现代劳动力所需的化学分析高级培训和技能。该研究项目的重点是有机硅吸附材料的合成和物理化学表征。该吸附剂将在核磁性纳米颗粒和核二氧化硅颗粒上合成，用于磁性固相萃取（SPE）和液相色谱（LC）。吸附剂材料将由二氧化硅杂化物组成，所述二氧化硅杂化物将具有特征性纤维/树枝状结构，同时在表面处含有叠氮化物化学官能团，充当与化学实体反应的平台，所述化学实体将通过“点击”化学（铜催化的叠氮化物-炔环缩合）改变材料的表面化学组成。有机二氧化硅表面将用化学官能团（例如，碳氟化合物、离子交换剂和极性部分），其将在液相分离中提供一组不同的混合模式相互作用。通过系统评价，使用成熟的技术（例如，红外光谱、元素分析、气体吸附分析和扫描电子显微镜），将确定材料的物理化学性质。LC和SPE将用于检查新合成材料的色谱和吸附性能，其中包括使用标准方案来评估材料的选择性和稳定性。该项目有望推进分离方法中使用的吸附材料领域的知识。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Professor Luis A. Colón and his research group at SUNY Buffalo are developing innovative organo-silica adsorptive materials. These materials are an essential component in separation methodology used in chemical analysis, which in turn is central to chemical, biological, environmental, pharmaceutical, and other related sciences. The materials are based on silica structures and designed to have useful physicochemical characteristics with the goal of improving the currently used separation media, with consideration in the chemical analysis of contaminants. The research approach is targeting a flexible platform on which different separation materials could be synthesized, bringing new possibilities for their use in specific practical applications. The research activities will engage graduate and undergraduate students, including members of traditionally underrepresented groups, providing advanced training and skills in chemical analysis necessary for the modern-day workforce in the academic, pharmaceutical, and industrial chemical sectors. The research project is focused on the synthesis and the physicochemical characterization of organo-silica adsorbent materials. The adsorbent will be synthesized on core magnetic nanoparticles and core silica particles to be used in magnetic solid phase extraction (SPE) and in liquid chromatography (LC). The adsorbent material will consist of a silica-hybrid that will have a characteristic fibrous/dendritic-type structure, while containing azide-chemical functionalities at the surface, serving as a platform to react with chemical entities that will alter the surface chemical composition of the material via “click” chemistry (copper-catalyzed azide-alkyne cyclocondensation). The organo-silica surface will be modified with chemical functionalities (e.g., fluorocarbons, ion exchangers, and polar moieties) that will provide a set of different mixed-mode interactions in liquid phase separations. Through a systematic evaluation, using well-established techniques (e.g., infrared spectroscopy, elemental analysis, gas adsorption analysis, and scanning electron microscopy) the physicochemical properties of the materials will be established. LC and SPE will be used to examine the chromatographic and adsorptive performance of the newly synthesized materials, which will include the use of standard protocols to assess the selectivity and stability of the materials. The project holds promise for advancing knowledge in the field of adsorbent materials for use in separation methods. The new materials will be used in chemical analysis, for example, in the analysis of pollutants and pharmaceutical compounds.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.