SGER: Apoenzyme-Based Molecular-Recognition Membranes for Enantioseparations

提案编号9714574提案类型SGER首席研究员Charles R. Martin隶属于科罗拉多州立大学该基金通过化学和运输系统分部界面、传输和分离项目的分离和净化项目子项目授予。首席研究员是科罗拉多州立大学的查尔斯·马丁博士。这项研究的目的是开发具有高度选择性的分子识别膜。其原理是将脱酶（不含辅助因子的酶）引入膜中。该脱酶与特定底物结合，从而与系统中存在的其他底物相比，增加了底物的通量。PI建议使用这种分子识别概念来专注于对映体分离，同时使用载脂蛋白和合成分子识别物种。这一开发对映选择性膜的建议具有很高的探索性。这里提出的研究对手性物种的分离具有潜在的巨大影响。分子识别和选择性分离的概念是分离科学与技术的新兴研究领域。如果成功，该研究将对药物纯化和生产规模产生重大影响。

Abstract Proposal No. 9714574 Proposal Type SGER Principal Investigator Charles R. Martin Affiliation Colorado State University This grant is awarded through the Separations and Purification Program sub-element of the Interfacial, Transport and Separations Program of the Chemical and Transport Systems Division. The principal investigator is Dr. Charles Martin at Colorado State University. The objective of the research is to develop molecular-recognition membranes that are highly selective. The concept is to introduce apoenzymes (enzymes without cofactors) into a membrane. The apoenzyme binds to specific substrates and thereby increases the flux of the substrate species compared to other species present in the system. The PI proposes to use this molecular recognition concept to focus on enantiomeric separations, using both apoenzymes and synthetic molecular recognition species. This proposal to develop enantioselective membranes ha a high exploratory content. The research proposed here has a potentially tremendous impact in the separation of chiral species. The concepts of molecular recognition and selective separations form emerging research areas in separations science and technology. If successful, the research will have a significant impact on pharamaceuticals purification and production scale-up.