SGER: Apoenzyme-Based Molecular-Recognition Membranes for Enantioseparations

摘要提案编号：9714574建议书类型SGER首席研究员查尔斯·R·马丁隶属于科罗拉多州立大学通过化学和运输系统部门界面、运输和分离计划的分离和净化计划子要素授予这笔赠款。首席研究员是科罗拉多州立大学的查尔斯·马丁博士。这项研究的目标是开发具有高度选择性的分子识别膜。其概念是将脱辅酶(不含辅因子的酶)引入膜中。脱辅酶与特定的底物结合，因此与系统中存在的其他物种相比，增加了底物物种的通量。PI建议使用这一分子识别概念，同时使用脱辅酶和合成分子识别物种，专注于对映体的分离。这项开发对映体选择性膜的建议具有很高的探索性内容。本文提出的研究对手性物种的分离具有潜在的巨大影响。分子识别和选择性分离的概念形成了分离科学和技术中的新兴研究领域。如果研究成功，将对法拉明类药物的提纯和生产放大产生重大影响。

Abstract Proposal No. 9714574 Proposal Type SGER Principal Investigator Charles R. Martin Affiliation Colorado State University This grant is awarded through the Separations and Purification Program sub-element of the Interfacial, Transport and Separations Program of the Chemical and Transport Systems Division. The principal investigator is Dr. Charles Martin at Colorado State University. The objective of the research is to develop molecular-recognition membranes that are highly selective. The concept is to introduce apoenzymes (enzymes without cofactors) into a membrane. The apoenzyme binds to specific substrates and thereby increases the flux of the substrate species compared to other species present in the system. The PI proposes to use this molecular recognition concept to focus on enantiomeric separations, using both apoenzymes and synthetic molecular recognition species. This proposal to develop enantioselective membranes ha a high exploratory content. The research proposed here has a potentially tremendous impact in the separation of chiral species. The concepts of molecular recognition and selective separations form emerging research areas in separations science and technology. If successful, the research will have a significant impact on pharamaceuticals purification and production scale-up.