SGER: Apoenzyme-Based Molecular-Recognition Membranes for Enantioseparations

SGER：基于脱辅基酶的分子识别膜，用于对映体分离

• 批准号: 9714574
• 负责人: Charles Martin
• 金额: $ 4.97万
• 依托单位: Colorado State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9714574&HistoricalAwards=false
• 关键词: SGER; Apoenzyme; Based; Molecular; Recognition

Abstract Proposal No. 9714574 Proposal Type SGER Principal Investigator Charles R. Martin Affiliation Colorado State University This grant is awarded through the Separations and Purification Program sub-element of the Interfacial, Transport and Separations Program of the Chemical and Transport Systems Division. The principal investigator is Dr. Charles Martin at Colorado State University. The objective of the research is to develop molecular-recognition membranes that are highly selective. The concept is to introduce apoenzymes (enzymes without cofactors) into a membrane. The apoenzyme binds to specific substrates and thereby increases the flux of the substrate species compared to other species present in the system. The PI proposes to use this molecular recognition concept to focus on enantiomeric separations, using both apoenzymes and synthetic molecular recognition species. This proposal to develop enantioselective membranes ha a high exploratory content. The research proposed here has a potentially tremendous impact in the separation of chiral species. The concepts of molecular recognition and selective separations form emerging research areas in separations science and technology. If successful, the research will have a significant impact on pharamaceuticals purification and production scale-up.

摘要 号提案 9714574提案类型 SGER首席研究员Charles R.马丁协会 科罗拉多州立大学 该补助金通过化学和运输系统司界面，运输和分离计划的分离和纯化计划子要素授予。 首席研究员是科罗拉多州立大学的查尔斯·马丁博士。 该研究的目的是开发具有高度选择性的分子识别膜。 其概念是将脱辅基酶（没有辅因子的酶）引入膜中。 脱辅基酶与特定底物结合，从而与系统中存在的其他物质相比增加底物物质的通量。 PI建议使用这种分子识别概念，专注于对映体分离，使用脱辅基酶和合成分子识别物种。 这一发展对映体选择性膜的设想具有很高的探索性。 本文提出的研究对手性物质的分离具有潜在的巨大影响。 分子识别和选择性分离的概念形成了分离科学和技术的新兴研究领域。 如果成功，该研究将对药物纯化和生产规模扩大产生重大影响。