A Nanomaterials/Nanoelectrochemical Route for Communication Between Biochemical Processes and IC Chips

用于生化过程和 IC 芯片之间通信的纳米材料/纳米电化学途径

• 批准号: 0087676
• 负责人: Charles Martin
• 金额: $ 77.04万
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0087676&HistoricalAwards=false
• 关键词: Nanomaterials; Nanoelectrochemical; Route; Communication; Between

AbstractProposal Title: XYZ on a Chip: A Nanomaterials/Nanoelectrochemical Route for Communication Between Biochemical Processes and IC ChipsProposal Number: CTS-0087676Principal Investigator: Charles MartinInstitution: University of FloridaThe development of arrays of electrochemical sensors based on nanomaterials to detect different analytes is to be demonstrated with biosensors. The unique aspect of this project is that the transduction of the binding event is accomplished directly on the chip. The team will develop processes based on redox sensors and electrochemical oligonucleotide sensors. Technical challenges include confinement of sensing elements to micron dimensions, signal transduction, and device control and signal processing. The proposed work in electrochemical sensor technology will establish an interface between electronics and electrolytes. A means to isolate and confine biochemical processes on chips for making amperometric measurements will be developed. Novel microelectrode configurations, previously developed by the PI, will be utilized in an array format for rapid assay experiments. The development of an on-chip potentiostat is proposed. Integration of an onboard controller, integrated circuit, and sensor is planned. This effort to provide electrical communication between biochemical processes and integrated-circuit technology may have applications in molecular electronics, biosensors, and bioartificial organs. The proposed work will complement the NSF Engineering Research Center at their institution. This project is co-funded by the Engineering Education and Centers Division.

提议标题：XYZ on a Chip：一种用于生化过程和IC芯片之间通信的纳米材料/纳米电化学途径提议编号：CTS-0087676主要研究员：Charles Martin研究所：佛罗里达大学基于纳米材料检测不同分析物的电化学传感器阵列的开发将用生物传感器进行演示。该项目的独特之处在于，结合事件的转导直接在芯片上完成。该团队将开发基于氧化还原传感器和电化学寡核苷酸传感器的过程。技术挑战包括将传感元件限制在微米尺寸、信号转导以及设备控制和信号处理。拟议中的电化学传感器技术工作将在电子和电解液之间建立一个接口。将开发一种分离和限制芯片上的生化过程进行安培测量的方法。PI以前开发的新型微电极配置将以阵列形式用于快速分析实验。介绍了一种片上恒电位仪的研制。计划集成车载控制器、集成电路和传感器。这种在生化过程和集成电路技术之间提供电子通信的努力可能会在分子电子学、生物传感器和生物人造器官中得到应用。这项拟议的工作将补充他们机构的NSF工程研究中心。该项目由工程教育和中心司共同资助。