A Nanomaterials/Nanoelectrochemical Route for Communication Between Biochemical Processes and IC Chips

摘要提案题目：芯片上的XYZ：生化过程与集成电路芯片之间通信的纳米材料/纳米电化学路线提案号：cts -0087676首席研究员：Charles martin机构：佛罗里达大学基于纳米材料的电化学传感器阵列的发展，以检测不同的分析物将与生物传感器一起进行演示。这个项目的独特之处在于，结合事件的转导直接在芯片上完成。该团队将开发基于氧化还原传感器和电化学寡核苷酸传感器的工艺。技术挑战包括将传感元件限制在微米尺寸，信号转导，以及设备控制和信号处理。电化学传感器技术的工作将在电子和电解质之间建立一个接口。将开发一种将生化过程隔离和限制在芯片上进行安培测量的方法。由PI先前开发的新型微电极配置将以阵列格式用于快速分析实验。提出了一种片上恒电位器的研制方案。计划集成板载控制器、集成电路和传感器。这种在生化过程和集成电路技术之间提供电子通信的努力可能在分子电子学、生物传感器和生物人造器官中得到应用。拟议的工作将补充其所在机构的国家科学基金会工程研究中心。该项目由工程教育和中心部共同资助。

AbstractProposal Title: XYZ on a Chip: A Nanomaterials/Nanoelectrochemical Route for Communication Between Biochemical Processes and IC ChipsProposal Number: CTS-0087676Principal Investigator: Charles MartinInstitution: University of FloridaThe development of arrays of electrochemical sensors based on nanomaterials to detect different analytes is to be demonstrated with biosensors. The unique aspect of this project is that the transduction of the binding event is accomplished directly on the chip. The team will develop processes based on redox sensors and electrochemical oligonucleotide sensors. Technical challenges include confinement of sensing elements to micron dimensions, signal transduction, and device control and signal processing. The proposed work in electrochemical sensor technology will establish an interface between electronics and electrolytes. A means to isolate and confine biochemical processes on chips for making amperometric measurements will be developed. Novel microelectrode configurations, previously developed by the PI, will be utilized in an array format for rapid assay experiments. The development of an on-chip potentiostat is proposed. Integration of an onboard controller, integrated circuit, and sensor is planned. This effort to provide electrical communication between biochemical processes and integrated-circuit technology may have applications in molecular electronics, biosensors, and bioartificial organs. The proposed work will complement the NSF Engineering Research Center at their institution. This project is co-funded by the Engineering Education and Centers Division.