The tumor pericyte and its role in tumor angiogenesis

肿瘤周细胞及其在肿瘤血管生成中的作用

• 批准号: 117345364
• 负责人: Professor Dr. Ralf H. Adams
• 金额: --
• 依托单位: Abteilung Gewebebiologie und Morphogenese
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/117345364?language=en
• 关键词: tumor; pericyte; its; role; angiogenesis

Pericytes are important support cells that stabilize capillaries in the healthy organism. Interactions between pericytes and the endothelium are loose in tumors, which is thought to enhance the leakiness and fragility of intratumor blood vessels. Pericytes are of great interest for the normalization of tumor vessels, an approach that might enhance the effect of circulating chemotherapeutics, or, alternatively, the destabilization of vessels that are protected against anti-angiogenic treatment. Here, we plan to investigate the dynamic behavior, fate and expression profile of pericytes in animal models of cancer. Genetic approaches in mice will be used for these studies as well as the functional characterization of Notch signaling in the tumor vasculature.

周细胞是稳定健康生物体内毛细血管的重要支持细胞。在肿瘤中，周细胞和内皮细胞之间的相互作用是松散的，这被认为增加了肿瘤内血管的泄漏和脆性。周细胞对肿瘤血管的正常化非常感兴趣，这是一种可能增强循环化疗药物效果的方法，或者是防止抗血管生成治疗的血管不稳定。在这里，我们计划研究周细胞在癌症动物模型中的动态行为、命运和表达谱。这些研究将使用小鼠的遗传学方法以及肿瘤血管系统中Notch信号的功能特征。