The tumor pericyte and its role in tumor angiogenesis

肿瘤周细胞及其在肿瘤血管生成中的作用

• 批准号: 117345364
• 负责人: Professor Dr. Ralf H. Adams
• 金额: --
• 依托单位: Abteilung Gewebebiologie und Morphogenese
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/117345364?language=en
• 关键词: tumor; pericyte; its; role; angiogenesis

Pericytes are important support cells that stabilize capillaries in the healthy organism. Interactions between pericytes and the endothelium are loose in tumors, which is thought to enhance the leakiness and fragility of intratumor blood vessels. Pericytes are of great interest for the normalization of tumor vessels, an approach that might enhance the effect of circulating chemotherapeutics, or, alternatively, the destabilization of vessels that are protected against anti-angiogenic treatment. Here, we plan to investigate the dynamic behavior, fate and expression profile of pericytes in animal models of cancer. Genetic approaches in mice will be used for these studies as well as the functional characterization of Notch signaling in the tumor vasculature.

周细胞是重要的支持细胞，稳定健康机体中的毛细血管。在肿瘤中周细胞和内皮之间的相互作用是松散的，这被认为是增强了肿瘤内血管的渗漏和脆弱性。周细胞对于肿瘤血管的正常化非常感兴趣，这是一种可能增强循环化疗剂的效果的方法，或者，替代地，保护免受抗血管生成治疗的血管的不稳定。在这里，我们计划调查的动态行为，命运和周细胞的表达谱在动物模型的癌症。小鼠中的遗传方法将用于这些研究以及肿瘤脉管系统中Notch信号传导的功能表征。