PECASE: Growth Control Regulated by p53 and MDM2

这份职业建议将实验室经验和研究融入亨特学院的本科生和研究生课程。这位研究者正在研究p53作为细胞周期检查点因子。本科生将研究p53对培养的哺乳动物细胞生长曲线的影响，并研究p53对转录激活的影响。研究生将研究诱导DNA损伤前后细胞周期中p53的分布，以及p53的DNA结合特性和磷酸化状态。这些研究将提供p53如何控制细胞生长的信息。这个职业奖将研究与亨特学院本科生和研究生的培训结合起来。由于亨特学院是一所少数族裔机构，许多未被充分代表的少数族裔将接受这项研究的培训，这项研究将提供有关蛋白质p53如何调节细胞周期的重要信息。＊＊＊

9722262 Bargonetti This career proposal is integrating laboratory experiences and research into undergraduate and graduate programs for students at Hunter college. This investigator is studying p53 as a cell cycle check point factor. The undergraduate students will examine the effect of p53 on the growth curves of mammalian cells in culture, and look at the effects of p53 on transcriptional activation. The graduate students will look at the distribution of p53 during the cell cycle in cells before and after induced DNA damage, and also look at the DNA binding properties and phosphorylation state of p53. These studies will provide information on how p53 controls cell growth. %%% This career award is combining the research with the training of undergraduate and graduate students at Hunter College. Since Hunter College is a minority institution, a number of underrepresented minorities will be trained in this research which will provide important information on how a protein, p53 acts to regulate the cell cycle. ***