PECASE: Growth Control Regulated by p53 and MDM2

PECASE：由 p53 和 MDM2 调节的生长控制

• 批准号: 9722262
• 负责人: Jill Bargonetti
• 金额: $ 48万
• 依托单位: CUNY Hunter College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9722262&HistoricalAwards=false
• 关键词: PECASE; Growth; Control; Regulated; p53

9722262 Bargonetti This career proposal is integrating laboratory experiences and research into undergraduate and graduate programs for students at Hunter college. This investigator is studying p53 as a cell cycle check point factor. The undergraduate students will examine the effect of p53 on the growth curves of mammalian cells in culture, and look at the effects of p53 on transcriptional activation. The graduate students will look at the distribution of p53 during the cell cycle in cells before and after induced DNA damage, and also look at the DNA binding properties and phosphorylation state of p53. These studies will provide information on how p53 controls cell growth. %%% This career award is combining the research with the training of undergraduate and graduate students at Hunter College. Since Hunter College is a minority institution, a number of underrepresented minorities will be trained in this research which will provide important information on how a protein, p53 acts to regulate the cell cycle. ***

小行星9722262 这个职业建议是将实验室经验和研究整合到亨特学院学生的本科和研究生课程中。 该研究者正在研究p53作为细胞周期检查点因子。 本科生将研究p53对培养的哺乳动物细胞生长曲线的影响，并研究p53对转录激活的影响。 研究生将研究p53在诱导DNA损伤前后细胞周期中的分布，并研究p53的DNA结合特性和磷酸化状态。 这些研究将提供关于p53如何控制细胞生长的信息。 %%% 该职业奖将研究与亨特学院本科生和研究生的培训相结合。由于亨特学院是一个少数民族机构，一些代表性不足的少数民族将在这项研究中接受培训，这将提供关于蛋白质p53如何调节细胞周期的重要信息。 ***