Odorant receptor complexes in olfactory cilia and axons

嗅觉纤毛和轴突中的气味受体复合物

• 批准号: 117800065
• 负责人: Professor Dr. Heinz Breer
• 金额: --
• 依托单位: Institut für Physiologie (230) (aufgelöst)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/117800065?language=en
• 关键词: Odorant; receptor; complexes; olfactory; cilia

The proposed research project is aimed to explore the molecular features of odorant receptor (OR) proteins segregated in the ciliary versus the axonal compartments of olfactory sensory neurons. Particular interest is focused on the proteins that are supposed to be associated with the OR, forming multimeric complexes in membranes of the cilia and axons. Exploring and identifying the molecular elements of such complexes are supposed to provide insight in molecular features determining the differential targeting and transfer mechanisms into the specific subcompartments. Furthermore, the receptor proteins in each compartment are supposed to be closely linked to distinct signalling elements. Since the proposed cellular response upon receptor activation is quite different for each compartment, it is most likely that at each location specific signalling cascades are involved. Identification of associated signalling elements would provide insight into these unexplored topics. Moreover, it will be of special interest to determine how these proposed protein complexes may be anchored onto the cytoskeleton; this appears to be of particular relevance in the axonal location, where the navigation processes of outgrowing axons as well as the interaxonal linkages may be affected via OR-mediated signalling processes.

拟议的研究项目旨在探索在嗅觉感觉神经元的睫状室和轴突室中分离的气味受体（OR）蛋白的分子特征。特别感兴趣的是那些被认为与 OR 相关的蛋白质，它们在纤毛和轴突的膜中形成多聚体复合物。探索和识别此类复合物的分子元件应该可以深入了解分子特征，从而确定不同的靶向和转移到特定子区室的机制。此外，每个区室中的受体蛋白应该与不同的信号元件紧密相连。由于每个区室在受体激活时所提出的细胞反应都非常不同，因此很可能在每个位置都涉及特定的信号级联。相关信号元件的识别将有助于深入了解这些未探索的主题。此外，确定这些提出的蛋白质复合物如何锚定到细胞骨架上将是特别令人感兴趣的；这似乎与轴突位置特别相关，其中生长轴突的导航过程以及轴突间的连接可能会通过 OR 介导的信号传导过程受到影响。

项目成果

Untypical connectivity from olfactory sensory neurons expressing OR37 into higher brain centers visualized by genetic tracing

• DOI: 10.1007/s00418-012-0919-2
• 发表时间: 2012-05-01
• 期刊: HISTOCHEMISTRY AND CELL BIOLOGY
• 影响因子: 2.3
• 作者: Bader, Andrea;Breer, Heinz;Strotmann, Joerg
• 通讯作者: Strotmann, Joerg

Connectivity from OR37 expressing olfactory sensory neurons to distinct cell types in the hypothalamus

• DOI: 10.3389/fncir.2012.00084
• 发表时间: 2012-11-16
• 期刊: FRONTIERS IN NEURAL CIRCUITS
• 影响因子: 3.5
• 作者: Bader, Andrea;Klein, Bettina;Strotmann, Joerg
• 通讯作者: Strotmann, Joerg