Regulation of Food Intake in Fish (Body Adiposity and Hormonal Network)

一些鱼类的生活史，如七鳃鳗、鲟鱼和鲑鱼，包括长时间的自愿禁食。 这些时期，通常与上游迁移到河流和产卵相一致，可能持续几个月，之后鱼要么恢复进食，要么死亡。 尽管进行了许多尝试，但仍然不知道是什么生态或生理信号抑制了食物摄入，然后在某些鱼类中再次启动。 该项目的目的是调查鱼类食物摄入量是否与代谢线索有关，主要是身体肥胖或受神经肽Y，胰岛素，瘦素和胰高血糖素样肽等激素的协调网络控制。 预期的结果将扩大在非哺乳类脊椎动物的食欲和食物摄入的调节的基本知识。 所提出的工作的实际应用，最终可能会给鱼类养殖优化饲养制度，因此，食物利用和身体组成的工具。 这反过来将减少鱼类食物的费用，尽可能地防止性成熟早期的体脂依赖现象，同时允许为人类生产健康的食物来源。

The life histories of a number of fish species such as lamprey, sturgeon, and salmon include prolonged periods of voluntary fasting. These periods, usually coincident with an upstream migration to the rivers and spawning, may last for several months after which the fish either restore feeding or expire. Despite many attempts, it remains unknown what ecological or physiological signals suppress food intake and later, in some fish species, initiate it again. The purpose of this project is to investigate whether fish food intake is linked to metabolic cues, primarily to body adiposity or controlled by coordinated network of hormones such as neuropeptide Y, insulin, leptin and glucagon-like peptide. The expected results will expand the basic knowledge of regulation of appetite and food intake in non-mammalian vertebrates. The practical application of the proposed work may eventually give fish culturists a tool for optimizing feeding regimes and, consequently, food utilization and body composition. This, in turn, will diminish expenses of fish food, prevent as much as possible the body fat dependent phenomenon of early sexual maturation, and at the same time permit production of healthful food sources for humans.