Funktionelle Differenzierung und Plastizität humaner Th17 Zellen

人Th17细胞的功能分化和可塑性

• 批准号: 118353741
• 负责人: Professorin Dr. Christina Zielinski
• 金额: --
• 依托单位: Institut für Mikrobiologie
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/118353741?language=en
• 关键词: Funktionelle; Differenzierung; und; Plastizit; humaner

T helper cells that produce IL-17 (Th17 cells) have recently emerged as a new T cell subset with roles in microbial defense and autoimmune diseases. The cellular and molecular factors driving human Th17 lineage specification have not been fully elucidated and remain highly controversial in light of reported discrepancies with the murine system. Strength and duration of T cell receptor signaling, antigen dose or type of co-stimulation are able to modulate Th1 and Th2 responses but have not been investigated in Th17 cells. MicroRNAs are increasingly recognized as important determinants of cell fate specification and might, like transcription factors, contribute to the functional differentiation of the Th17 cell subset. Therefore the aim will be to decipher the requirements for Th17 cell commitment at a cellular and molecular level. Questions related to Th17 cell lineage maintenance will be addressed by studying the plasticity of this new T helper cell subset. This study will provide insights into the events initiating autoimmunity, potentially yielding novel therapeutic targets for immune vaccination strategies.

产生IL-17的辅助性T细胞（Th 17细胞）最近作为一种新的T细胞亚群出现，在微生物防御和自身免疫性疾病中发挥作用。驱动人类Th 17谱系特化的细胞和分子因子尚未完全阐明，并且鉴于与鼠系统的报道差异，仍然存在高度争议。T细胞受体信号传导的强度和持续时间、抗原剂量或共刺激的类型能够调节Th 1和Th 2应答，但尚未在Th 17细胞中进行研究。MicroRNA被越来越多地认为是细胞命运规范的重要决定因素，并且可能与转录因子一样，有助于Th 17细胞亚群的功能分化。因此，目标将是在细胞和分子水平上破译Th 17细胞定型的要求。与Th 17细胞谱系维持相关的问题将通过研究这种新的T辅助细胞亚群的可塑性来解决。这项研究将提供对引发自身免疫的事件的见解，可能为免疫疫苗接种策略产生新的治疗靶点。