ERA NanoSci - Magnetic nanoparticles for nerve regeneration

生物工程研究正在探索替代外科神经移植治疗严重周围神经损伤的分子和细胞疗法。然而，到目前为止，还没有取得临床上毫无疑问的好处的进展。纳米科学的最新进展可能提供新的治疗可能性，作为现有外科技术的替代/补充。具体地说，Marvene项目涉及使用磁性纳米颗粒(MNPs)作为功能纳米对象来增强神经再生并为再生轴突提供指导。MNPs可以利用作用于MNPs神经元的机械力来促进轴突的伸长/生长，从而为新的治疗开辟新的前沿。此外，通过神经营养因子功能化的MNPs的实现为新的分子治疗提供了独特的可能性，当MNPs与间充质干细胞结合时，MNPs可能形成更有效的细胞治疗的基础。

Bioengineering research is exploring molecular and cell therapies alternative to surgical nerve grafting for the treatment of severe peripheral nerve injuries. However, to date there has been no progress of undoubted clinical benefit. The recent advances in nanoscience may provide new therapeutic possibilities as alternatives/supplements to established surgical techniques. Specifically, the MARVENE project is concerned with the use of magnetic nanoparticles (MNPs) as functional nano-objects to enhance the nerve regeneration and provide guidance for the regenerating axons. MNPs could open the frontiers for new therapies based on the exploitation of the mechanical forces acting on MNPbound neurons to promote axonal elongation/growth. Furthermore, the realization of MNPs functionalised with neurotrophic factors offer distinct possibilities for novel molecular therapy and when bound to mesenchymal stem cells, MNPs may form the basis for more effective cell therapy.