U.S.-France Cooperative Research: Influence of the Allylic C-F Bond on the Reactivity & Stereoselectivity of Cycloadditions & Nucleophilic, Electrophilic, & Radical Additions

这个为期三年的奖项为美法在有机反应速率和机制方面的合作研究提供支持。 该项目由加州大学洛杉矶分校的 Kendall N. Houk 和法国雷恩国立高等化学学院的 Rene Gree 组成的研究小组组成。 通过将氟引入分子中，研究人员将分析烯丙基键对烯烃反应的反应性和立体选择性的影响。他们将专门讨论环加成和加成反应。 这位美国研究人员为此次合作带来了理论和计算化学方面的专业知识。 理论工作将为实验研究提供有趣系统的预测。 法国研究人员进行的系统实验研究将对此进行补充，该研究利用他们独特的方法将烯丙基氟引入分子中。 该项目可能会导致开发一种供制药和材料研究界使用的新合成方法。

This three-year award provides support for US-France cooperative research on organic reaction rates and mechanisms. It involves the research groups of Kendall N. Houk at the University of California, Los Angeles, and Rene Gree at the Ecole Nationale Superieure de Chimie in Rennes, France. By introducing fluorine into molecules, the investigators will analyze the influence of allylic bonds on the reactivity and stereoselectivity of alkene reactions. They will specifically address cycloaddition and addition reactions. The US investigator brings to this collaboration expertise in theoretical and computational chemistry. The theoretical work will provide prediction of interesting systems for experimental studies. This will be complemented by systematic experimental studies performed by the French investigators, which takes advantage of their unique methodology for introducing allylic fluorine into molecules. The project could lead to the development of a new synthetic methodology of use to the pharmaceutical and materials research communities.