U.S.-France Cooperative Research: Influence of the Allylic C-F Bond on the Reactivity & Stereoselectivity of Cycloadditions & Nucleophilic, Electrophilic, & Radical Additions

美法合作研究：烯丙基C-F键对反应活性的影响

• 批准号: 9726799
• 负责人: Kendall Houk
• 金额: $ 1万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2004-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9726799&HistoricalAwards=false
• 关键词: U.S.; France; Cooperative; Research; Influence

This three-year award provides support for US-France cooperative research on organic reaction rates and mechanisms. It involves the research groups of Kendall N. Houk at the University of California, Los Angeles, and Rene Gree at the Ecole Nationale Superieure de Chimie in Rennes, France. By introducing fluorine into molecules, the investigators will analyze the influence of allylic bonds on the reactivity and stereoselectivity of alkene reactions. They will specifically address cycloaddition and addition reactions. The US investigator brings to this collaboration expertise in theoretical and computational chemistry. The theoretical work will provide prediction of interesting systems for experimental studies. This will be complemented by systematic experimental studies performed by the French investigators, which takes advantage of their unique methodology for introducing allylic fluorine into molecules. The project could lead to the development of a new synthetic methodology of use to the pharmaceutical and materials research communities.

这个为期三年的奖项为美国和法国在有机食品方面的合作研究提供支持。 反应速率和机制。 它涉及的研究小组的肯德尔N。Houk at the 加州大学，洛杉矶，和雷内·格里在国立圣地亚哥大学 de Chimie in Rennes，法国 通过在分子中引入氟， 分析烯丙基键对烯烃反应活性和立体选择性的影响 反应.它们将具体说明环加成和加成反应。 美国调查员为这一合作带来了理论和 计算化学 理论工作将提供有趣的预测 系统进行实验研究。 这将通过系统的实验来补充 法国研究人员进行的研究，利用其独特的 将烯丙基氟引入分子的方法。 该项目可能导致 开发一种新的合成方法，用于药物和 材料研究社区。