Cyclophanes to Study Principles of Molecular Recognition in Aqueous Solutions

在这个有机动力学项目中， 弗朗索瓦·N Diederich将调查“Cyclophanes研究 水溶液中的分子识别原理”， 洛杉矶加州大学化学系 洛杉矶（UCLA）. 分子识别是研究设计的 两个或两个之间形成的多分子实体和组装体 更多的化学物种，并通过分子间的 力，非共价键。 这个迷人而充满活力的 研究领域被世界公认为一个重要的 知识和技术前沿。 这些 研究将为新主机的设计提供指导方针， 对生物分子运作的新见解。 这 这些信息对那些科学家来说特别有价值 对设计新的受体来选择性地去除 来自人类废水沃茨或体液的有毒分子。 本研究涉及一个全面的合成，物理 有机和计算方法来解释非极性 在水溶液中络合。 水的作用将是 在水溶液和有机溶液的比较研究中定义 解决方案 对于这些研究，一系列独特的环蕃 具有非极性结合腔的受体已经是可用的， 其他人将准备达到特定的目标。 滴定微量热法用于精确 热力学量全集的确定 用于水溶液和有机溶液中的非极性络合过程 解决方案 氢-氘同位素、盐和缓冲液 对非极性缔合的影响也正在研究中。

In this project in the Organic Dynamics Program, Professor Francois N. Diederich will investigate "Cyclophanes to Study Principles of Molecular Recognition in Aqueous Solutions" in the Chemistry Department at the University of California, Los Angeles (UCLA). Molecular recognition is the study of designed polymolecular entities and assemblies formed between two or more chemical species and held together by intermolecular forces, the noncovalent bond. This fascinating and dynamic research area is recognized worldwide as an important intellectual and technological frontier in chemistry. These studies will lead to guidelines for the design of new hosts and to new insight into the workings of biological molecules. This information is especially valuable for those scientists interested in designing new receptors to selectively remove toxic molecules from waste waters or bodily fluids in humans. This study involves a comprehensive synthetic, physical organic, and computational approach to explain apolar complexation in aqueous solutions. The role of water will be defined in comparative investigations in aqueous and organic solutions. For these studies, a unique series of cyclophane receptors with apolar binding cavities is already available, and others will be prepared to reach specific objectives. Titration microcalorimetry is being used for accurate determination of the complete set of thermodynamic quantities for apolar complexation processes in aqueous and organic solutions. Hydrogen-deuterium isotope, salt, and buffer effects on apolar association are also being studied.