Parallel Cortical Pathways Through the Pulvinar/LP Complex

通过 Pulvinar/LP 复合体的平行皮质通路

• 批准号: 9728089
• 负责人: Martha Bickford
• 金额: $ 23.26万
• 依托单位: University of Louisville Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-02-15 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9728089&HistoricalAwards=false
• 关键词: Parallel; Cortical; Pathways; Through; Pulvinar

LAY ABSTRACT Principal Investigator: Bickford, Martha Proposal Number: IBN- 9728089 PARALLEL CORTICAL PATHWAYS THROUGH THE PULVINAR COMPLEX Most sensory signals must pass through the dorsal thalamus before they are consciously recognized in the cortex. It has been known for a number of years that sensory signals from peripheral receptors are segregated, and travel in parallel pathways through the relay nuclei of the dorsal thalamus, to primary sensory areas of cortex. The study of parallel pathways in sensory system, particularly in the visual system, has provided a key to understanding how the brain codes the wide variety of incoming information. The realization that features such as color, motion, or contrast are coded by separate subcortical cell types has provided a valuable conceptual framework for studies of how visual signals are perceived by the brain. This proposal tests the hypothesis that similar parallel pathways exist in areas of the thalamus that associate information from a variety of cortical areas. In this case, the proposed parallel pathways originate in cortex, and remain segregated in the thalamus through synaptic contacts on distinct classes of thalamocortical neurons, which project to different cortical laminae. This idea will be tested in the pulvinar and lateral posterior nuclei, which receive input from two types of layer V cortical cells, and contain at least two morphologically distinct types of thalamocortical cells. It is proposed that separate cortical axons contact separate classes of thalamocortical cells that project to different cortical lamina. The proposed anatomical experiments, which involve the injection of neuroanatomical tracers and irnmunocytochemistry, wi ll test the concept that parallel pathways are utilized in the processing of internal cortical signals. It is anticipated that, similar to the study of parallel sensory pathways, this information will provide a fruitful starting point for deciphering the function of the pulvinar and lateral posterior nuclei.

简单摘要 主要研究者：Bickford，Martha 提案编号： IBN- 9728089 通过枕复合体的平行皮质通路 大多数感觉信号必须通过背侧丘脑 大脑皮层才能有意识地识别它们。 已经 多年来，我们都知道来自外周神经的感觉信号 受体是分离的，并通过平行的途径旅行， 背侧丘脑的中继核，到初级感觉区， 皮层 的 研究 平行的路径， 感官 系统， 特别 在 视觉系统，提供了 一 关键 到 了解大脑是如何编码各种各样的传入信息的 信息.认识到诸如颜色、运动或 对比度是由不同的皮层下细胞类型编码的， 有价值的概念框架，研究视觉信号是如何 被大脑感知。 这一提议检验了以下假设： 类似的平行通路存在于丘脑的区域， 将来自不同皮层区域的信息联系起来。在这种情况下， 提出的平行通路起源于皮层， 在丘脑中通过突触接触分离在不同的 类 丘脑皮层神经元的神经元， 皮层 这个想法将在枕上进行测试， 外侧后核，其接收来自两种类型层的输入 V皮质细胞，并含有至少两个形态上不同的 丘脑皮质细胞的类型。有人建议， 轴突接触不同类别的丘脑皮质细胞， 到不同的皮层。拟议中的解剖学实验， 这 涉及 的 神经解剖注射 示踪剂 和 免疫细胞化学，将测试平行途径的概念， 被用于处理内部皮层信号。 是 与平行感觉通路的研究类似， 这 信息将提供一个富有成效的开始 点 为 解读枕和侧后的功能 原子核。