Design and Oligomerization of Uniquely Folded Supersecondary Structural Motifs
独特折叠超二级结构基序的设计和寡聚化
基本信息
- 批准号:9729324
- 负责人:
- 金额:$ 21.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-01-01 至 1999-07-20
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The foci of this research are twofold. First, the development of new independently folded polypeptide motifs will be carried out. The two design targets are an all beta-structure (BBB) motif and a mixed alpha- and beta- structure patterned after charybotoxin which includes a number of disulfides in the native state. Second, the structure of the BBA motif will be manipulated to effect the formation of a discrete dimeric structure by `domain swapping.` A key feature of the dimerization studies will be the development of fluorescent amino acids with solvatochromic properties for studying protein association phenomena. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Barbara Imperiali of the Division of Chemistry at the California Institute of Technology. Professor Imperiali will focus her work on designing and developing methods for the de novo synthesis of functional polypeptides. The detailed analysis of the cooperative forces involved in folding small oligopeptides into compact structures will contribute to the understanding of the architecture of the protein biopolymer.
这项研究的重点是双重的。首先,将进行新的独立折叠多肽基序的开发。这两个设计目标是一个全β -结构(BBB)基序和一个混合α -和β -结构图案后的charybotoxin,其中包括一些天然状态的二硫化物。其次,BBA基序的结构将通过“结构域交换”来影响离散二聚体结构的形成。二聚化研究的一个关键特征将是开发具有溶剂致变色性质的荧光氨基酸,用于研究蛋白质结合现象。有了这个更新奖,有机和大分子化学项目支持加州理工学院化学系芭芭拉·Imperiali博士的研究。Imperiali教授将专注于设计和开发功能多肽从头合成的方法。详细分析小寡肽折叠成紧凑结构时所涉及的协同力将有助于理解蛋白质生物聚合物的结构。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Barbara Imperiali其他文献
Defining early steps in emBacillus subtilis/em biofilm biosynthesis
定义枯草芽孢杆菌生物膜生物合成的早期步骤
- DOI:
10.1128/mbio.00948-23 - 发表时间:
2023-09-22 - 期刊:
- 影响因子:4.700
- 作者:
Christine A. Arbour;Rupa Nagar;Hannah M. Bernstein;Soumi Ghosh;Yusra Al-Sammarraie;Helge C. Dorfmueller;Michael A. J. Ferguson;Nicola R. Stanley-Wall;Barbara Imperiali - 通讯作者:
Barbara Imperiali
Barbara Imperiali的其他文献
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{{ truncateString('Barbara Imperiali', 18)}}的其他基金
Collaborative Research: Development of a platform enabling analysis of membrane protein interactions
合作研究:开发能够分析膜蛋白相互作用的平台
- 批准号:
1615252 - 财政年份:2016
- 资助金额:
$ 21.12万 - 项目类别:
Standard Grant
Collaborative Research: Lanthanide Binding Tags: Biophysical Tools for Investigating Protein Structure and Function
合作研究:镧系元素结合标签:研究蛋白质结构和功能的生物物理工具
- 批准号:
0744483 - 财政年份:2008
- 资助金额:
$ 21.12万 - 项目类别:
Continuing Grant
Mini-protein scaffolds for protein design
用于蛋白质设计的微型蛋白质支架
- 批准号:
0414243 - 财政年份:2004
- 资助金额:
$ 21.12万 - 项目类别:
Continuing Grant
Lanthanide Binding Tags: New Chemical Tools for Proteomics
镧系元素结合标签:蛋白质组学的新化学工具
- 批准号:
0304832 - 财政年份:2003
- 资助金额:
$ 21.12万 - 项目类别:
Continuing Grant
Design and Oligomerization of Uniquely Folded Supersecondary Structural Motifs
独特折叠超二级结构基序的设计和寡聚化
- 批准号:
0100735 - 财政年份:2001
- 资助金额:
$ 21.12万 - 项目类别:
Continuing grant
Development of Multi-User Facility for the Study of Complex Macromolecular Systems
用于复杂大分子系统研究的多用户设施的开发
- 批准号:
0070319 - 财政年份:2000
- 资助金额:
$ 21.12万 - 项目类别:
Standard Grant
Design and Oligomerization of Uniquely Folded Supersecondary Structural Motifs
独特折叠超二级结构基序的设计和寡聚化
- 批准号:
9996335 - 财政年份:1999
- 资助金额:
$ 21.12万 - 项目类别:
Continuing grant
De Novo Protein Synthesis: Design and Assembly of Uniquely Folded Supersecondary Structural Motifs
从头蛋白质合成:独特折叠超二级结构基序的设计和组装
- 批准号:
9412442 - 财政年份:1994
- 资助金额:
$ 21.12万 - 项目类别:
Continuing Grant
Utilization of Unnatural Amino Acids in de novo Protein Synthesis
非天然氨基酸在蛋白质从头合成中的利用
- 批准号:
9104445 - 财政年份:1991
- 资助金额:
$ 21.12万 - 项目类别:
Continuing Grant
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