CAREER: Analysis and Design of Matrix Microstructure in Tissue Engineering

9733007莫赫，这一职业奖的研究计划是开发一种技术，以定量评估可生物降解组织模拟基质中的基质微结构和相应的细胞活动。具体目标是：(1)开发一种新的成像方法来定量研究生理条件下三维可生物降解多孔组织类似物的拓扑和体微结构；(2)设计新的聚合物基质的微结构构型，以促进培养的肝细胞的表型和功能；以及(3)研究聚合物降解对拓扑和体基质微结构的影响以及局部物理化学条件对肝细胞生理的影响。就该奖项的教学部分而言，其具体目标是：(1)在整个大学范围内开发一门以生物材料工程为重点的创新组织工程课程；(2)为地区高中的学生设立一门新课程，目的是向选定的学生提供生物工程这一结合生命科学、物理科学和数学的领域的广泛研究；以及(3)通过基于互联网的网络，通过远程教学扩大到其他大学和高中的教学范围。***

9733007 Moghe The research program of this career award is to develop a technology to quantitatively evaluate matrix microstructure and the corresponding cellular activities within biodegradable tissue analog matrices. Specific aims are to: (1) develop a novel imaging methodology to quantitatively investigate topological and bulk microstructure of 3-D biodegradable porous tissue analogs under physiological conditions; (2) design novel microstructural configurations of polymeric matrices that promote the phenotype and functions of cultured liver cells; and (3) examine the effect of polymer degradation on the topological and bulk matrix microstructure and the local physico-chemical conditions to the physiology of liver cells. For the teaching component of this award, the specific aims are to: (1) develop an innovative university-wide curriculum in Tissue Engineering which reflects a focus on biomaterials engineering; (2) establish a new course for students from regional high schools with the goal of offering to selected students a broad study of bioengineering as a field combining life sciences with the physical sciences and mathematics; and (3) extend outreach to other universities and high schools by distance instruction through an internet- based network. ***