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Physical Organic Chemistry of Fischer Carbene Complexes

费歇尔卡宾配合物的物理有机化学

基本信息

批准号：
9734822
负责人：
Claude Bernasconi
金额：
$ 36.65万
依托单位：
University of California-Santa Cruz
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
1998
资助国家：
美国
起止时间：
1998-08-01 至 2001-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9734822&HistoricalAwards=false
关键词：
Physical Organic Chemistry Fischer Carbene

项目摘要

This research focuses on elucidating the mechanisms by which metallocarbenes of the group-six triad undergo hydrolysis and facilitate nucleophilic additions. Electron donating and accepting properties of the coordinated carbene will be varied through systematic modifications of the groups appendant to the carbene carbon and correlated with the kinetic and thermodynamic acidities of the complexes to develop structure-reactivity relationships. Graduate students and postdoctoral research associates carrying out the experiments will be introduced to the synthesis of organometallic carbene complexes and to the procedures used to elucidate the general patterns of their chemical reactivity. With this award, the Organic and Macromolecular Chemistry Program supports the research of Dr. Claude Bernasconi of the Department of Chemistry at the University of California at Santa Cruz. Dr. Bernasconi will focus his research on correlating the reactivity of chromium, molybdenum and tungsten carbene complexes with the structure of the attached carbene. These complexes, which contain an unusual, reactive form of carbon, facilitate certain organic transformations and are finding an increasing use in synthetic organic chemistry. Dr. Bernasconi's educational activities include the training of graduate and postdoctoral students in organometallic syntheses and the procedures used to elucidate their chemistry.

这项研究的重点是阐明机制，第六族三单元组的双卡宾经历水解并促进亲核加成的给电子和接受电子性质配位卡宾将通过系统修饰而变化的基团附属于碳烯碳和相关的络合物的动力学和热力学酸度结构-反应性关系研究生和博士后进行实验的研究人员将被介绍给有机金属卡宾配合物的合成和方法用于阐明其化学反应性的一般模式。有了这个奖项，有机和高分子化学计划支持克劳德·伯纳斯科尼博士的研究，在圣克鲁斯的加州大学学习化学。伯纳斯科尼医生他的研究重点将是铬的反应性相关性，具有以下结构的钼和钨碳烯络合物：连接卡宾。这些复合物含有一种不寻常的，碳的形式，促进某些有机转化，并发现在合成有机化学中的应用越来越多。伯纳斯科尼医生教育活动包括培训研究生和有机金属合成博士后研究来阐明它们的化学性质