Structure-Reactivity Relationships in Carbanion-Forming Reactions

在有机化学和高分子化学项目的支持下，加州大学圣克鲁斯分校化学和生物化学系的克劳斯·F·贝纳斯科尼教授正在探索碳负离子形成反应中的结构-活性关系。他的研究集中在Fischer-型卡宾络合物的去质子化，这种络合物提供中性卡宾(通过电子供体)和相应的阴离子(通过离域)的稳定。人们正在通过实验和计算相结合的方法来探索供电子和吸电子基团之间的复杂相互作用，这导致了不寻常的反应模式。碳离子是带负电荷的分子，在有机和金属有机化学中具有核心作用。它们可以由许多反应产生，包括，也许最常见的，从分子中除去一个质子(“去质子化”)。在某些情况下，生成的碳负离子足够稳定，可以进行观察，从而可以测量其性质，从而获得有关反应机理的重要信息。加州大学圣克鲁斯分校化学和生物化学系的克劳德·F·贝纳斯科尼教授在有机化学和高分子化学计划的支持下，正在研究这种碳负离子形成反应。他的研究解决了有关化学反应及其如何受分子结构影响的基本问题，此外还为学生提供了广泛的教育经验，从合成和光谱表征到动力学、数据分析和计算化学。

With the support of the Organic and Macromolecular Chemistry Program, Professor Clause F. Bernasconi, of the Department of Chemistry and Biochemistry at the University of California, Santa Cruz, is exploring structure-activity relationships in carbanion forming reactions. His studies focus on the deprotonation of Fischer-type carbene complexes, which offer stabilization of both the neutral carbene (through electron donation) and the corresponding anion (through delocalization). The complex interplay between electron donating and electron withdrawing groups, which leads to unusual reactivity patterns, is being explored through a combination of experimental and computational methods.Carbanions are negatively charged molecules that are of central importance in organic and organometallic chemistry. They can be generated by a number of reactions, including, perhaps most commonly, the removal of a proton from a molecule ("deprotonation"). In some cases, the resulting carbanion is sufficiently stable to allow its observation, permitting the measurement of its properties and thereby yielding important information about reaction mechanisms. Professor Claude F. Bernasconi, of the Department of Chemistry and Biochemistry at the University of California, Santa Cruz, is studying such carbanion forming reactions with the support of the Organic and Macromolecular Chemistry Program. His studies address fundamental questions about chemical reactions and how they are affected by molecular structure, and in addition provide students with a broad educational experience, ranging from synthesis and spectroscopic characterization to kinetics, data analysis, and computational chemistry.