Structure-Reactivity Relationships in Carbanion-Forming Reactions

碳负离子形成反应中的结构-反应性关系

• 批准号: 0098553
• 负责人: Claude Bernasconi
• 金额: $ 40.57万
• 依托单位: University of California-Santa Cruz
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0098553&HistoricalAwards=false
• 关键词: Structure; Reactivity; Relationships; Carbanion; Forming

With the support of the Organic and Macromolecular Chemistry Program, Professor Clause F. Bernasconi, of the Department of Chemistry and Biochemistry at the University of California, Santa Cruz, is exploring structure-activity relationships in carbanion forming reactions. His studies focus on the deprotonation of Fischer-type carbene complexes, which offer stabilization of both the neutral carbene (through electron donation) and the corresponding anion (through delocalization). The complex interplay between electron donating and electron withdrawing groups, which leads to unusual reactivity patterns, is being explored through a combination of experimental and computational methods.Carbanions are negatively charged molecules that are of central importance in organic and organometallic chemistry. They can be generated by a number of reactions, including, perhaps most commonly, the removal of a proton from a molecule ("deprotonation"). In some cases, the resulting carbanion is sufficiently stable to allow its observation, permitting the measurement of its properties and thereby yielding important information about reaction mechanisms. Professor Claude F. Bernasconi, of the Department of Chemistry and Biochemistry at the University of California, Santa Cruz, is studying such carbanion forming reactions with the support of the Organic and Macromolecular Chemistry Program. His studies address fundamental questions about chemical reactions and how they are affected by molecular structure, and in addition provide students with a broad educational experience, ranging from synthesis and spectroscopic characterization to kinetics, data analysis, and computational chemistry.

在有机和高分子化学项目的支持下，Clause F.位于圣克鲁斯的加州大学化学和生物化学系的Bernasconi正在探索碳负离子形成反应中的结构-活性关系。他的研究重点是Fischer型卡宾络合物的去质子化，该络合物提供中性卡宾（通过电子供体）和相应阴离子（通过离域）的稳定。供电子基团和吸电子基团之间复杂的相互作用，导致了不寻常的反应模式，正通过实验和计算方法的结合进行探索。碳负离子是带负电荷的分子，在有机化学和有机金属化学中具有核心重要性。它们可以通过许多反应产生，包括，也许最常见的，从分子中去除质子（“去质子化”）。在某些情况下，产生的负碳离子足够稳定，可以观察到，允许测量其性质，从而产生有关反应机制的重要信息。Claude F.位于圣克鲁斯的加州大学化学和生物化学系的Bernasconi在有机和大分子化学项目的支持下，正在研究这种碳负离子形成反应。他的研究解决了有关化学反应的基本问题以及它们如何受到分子结构的影响，此外还为学生提供了广泛的教育经验，从合成和光谱表征到动力学，数据分析和计算化学。