Structure-Reactivity Behavior of Stabilized Carbanions

在这个有机动力学项目中， 化学部，教授克劳德F。伯纳斯科尼在 美国加州大学化学系 克鲁兹将研究“质子转移动力学和 烯烃在溶液和气体中的亲核加成反应 阶段”。 存在着特征关系， 反应物的结构和碳酸 去质子化得到碳负离子。 这项研究如何 共振和溶剂化作用影响碳负离子形成反应性 反应将增加我们对化学反应性的理解 （反应机制）一般而言。 本项目将侧重于结构-活性关系， 负碳离子的共振稳定和溶剂化， 碱的溶剂化状态（质子转移）或 亲核试剂（加成反应），特别是 与碳负离子形成反应有关。 的一般性的 这表明大部分的结构-反应性行为 碳负离子形成反应的控制因素是缺乏 键合形成过程和其他过程之间的同步 诸如共振发展，溶剂化， 分子内氢键形成、空间效应等， 将被仔细检查和量化。

In this project in the Organic Dynamics Program of the Chemistry Division, Professor Claude F. Bernasconi in the Chemistry Department of the University of California, Santa Cruz will study the "Kinetics of Proton Transfer and Nucleophilic Additions to Olefins in Solution and in the Gas Phase". There exist characteristic relationships between the structure of the reactants and the rates at which carbon acids are deprotonated to afford carbanions. This study of how resonance and solvation affect reactivity in carbanion-forming reactions will add to our understanding of chemical reactivity (reaction mechanisms) in general. This project will focus on structure-activity relationships, resonance stabilization and solvation of the carbanion, the solvational state of the base (proton transfers) or the nucleophile (addition reactions) which are particularly pertinent to carbanion-forming reactions. The generality of the suggestion that much of the structure-reactivity behavior of carbanion-forming reactions is governed by a lack of synchronization between bond forming processes and other factors such as resonance development, solvation, intramolecular hydrogen bond formation, steric effects, etc., will be scrutinized and quantified.