High Field NMR Across the Undergraduate Curriculum

300兆赫傅立叶变换核磁共振光谱仪广泛应用于化学、生物、人体营养学和医学技术等专业的课程中，以提高教学质量。该项目的目标是：通过让学生接触这一强大的结构测定工具来激发他们对化学的兴趣，训练他们掌握现代核磁共振波谱的理论、方法和应用，并将这一结构工具与分子建模相结合，使他们对化学科学有更广阔的视野。核磁共振波谱仪是第一次介绍给学生在普通化学合作实验室计划。有机专业大二学生使用该仪器获取质子和C-13光谱用于产品分析，并通过COSY实验介绍了二维核磁共振。然后，学生在无机实验室中使用变温核磁共振来探索无机系统的结构和流动行为。在物理化学实验室中，学生使用变温核磁共振获得N，N-二甲基乙酰胺内部旋转的动力学和热力学数据。在仪器分析中，学生使用仪器研究时域和频域频谱之间的关系以及信号平均和数字滤波。重点放在使用核磁共振结合分子建模提供机会，让学生探索结构和光谱之间的关系。＊

The 300 MHz Fourier transform NMR spectrometer is used in a wide range of courses to improve the quality of education for students majoring in chemistry, biology, human nutrition, and medical technology. the objectives of this project are: to excite students about chemistry by exposing them to this powerful tool for structure determination, to train them in the theory, methods, and application of modern NMR spectroscopy, and to combine this structural tool with molecular modeling to give them a broader perspective of chemical science. The NMR spectrometer is first introduced to students in the General Chemistry cooperative laboratory program. Sophomore organic students use the instrument to obtain proton and C-13 spectra for product analysis and are also introduced to two-dimensional NMR through a COSY experiment. Students then use variable temperature NMR in the inorganic laboratory to explore the structural and fluxional behavior of inorganic systems. In the physical chemistry laboratory, students use variable temperature NMR to obtain kinetic and thermodynamic data for the internal rotations in N,N-dimethylacetamides. In instrumental analysis, students use the instrument to study the relationships between time and frequency domain spectra as well as signal averaging and digital filtering. Emphasis is placed on using the NMR in conjunction with molecular modeling to provide the opportunity for students to explore the relationship between structure and spectra. *