Template Oligomerization for the Replication of Precisely Defined Synthetic Macromolecules

用于复制精确定义的合成大分子的模板寡聚化

• 批准号: 9803196
• 负责人: James Tour
• 金额: $ 33.6万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-15 至 1999-10-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9803196&HistoricalAwards=false
• 关键词: Template; Oligomerization; Replication; Precisely; Defined

The focus of this research is the use of precisely defined templates for the production of organic oligomers of precise molecular weight and constitution. Rigid-rod oligomer templates will be used for the rapid construction of oligomers having the same length as the templates. Monomers will be attached to the templates via covalent bonds, then oligomerization will be chemically induced to afford a supramolecular parent-daughter duplex. Cleavage of the parent-daughter duplex would produce a daughter oligomer that retains the specific length information of the parent template. Methods are proposed to reuse the parent template and the daughter as a new template, thus making the entire process catalytic in template, and ultimately similar to the polymerase chain reaction (PCR) in its productive capabilities. The project could significantly simplify the preparation of precisely defined macromolecular architectures which are currently prepared only by laborious step-wise procedures or multiple analytical separations. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. James M. Tour of the Department of Chemistry and Biochemistry at the University of South Carolina. Professor Tour will focus his work on developing new routes for the facile construction of organic oligomers of precise molecular weight and constitution. These precise macromolecular systems are becoming important for electronics, photonics, molecular electronics, catalysis, separation science, nano-engineering, and nano-bioengineering

这项研究的重点是使用精确定义的模板来生产具有精确分子量和组成的有机低聚物。 刚性棒寡聚物模板将用于快速构建与模板具有相同长度的寡聚物。 单体将通过共价键连接到模板上，然后化学诱导寡聚反应以提供超分子亲子双链体。 母体-子体双链体的切割将产生保留母体模板的特定长度信息的子体寡聚体。 提出了将母模板和子模板重复使用作为新模板的方法，从而使整个过程在模板中催化，最终在其生产能力上类似于聚合酶链式反应（PCR）。 该项目可以显着简化精确定义的大分子结构的制备，目前这些结构只能通过费力的逐步程序或多次分析分离来制备。 有机与高分子化学项目通过该奖项支持南卡罗来纳大学化学与生物化学系 James M. Tour 博士的研究。 图尔教授的工作重点是开发新路线，以方便构建具有精确分子量和组成的有机低聚物。 这些精确的大分子系统对于电子学、光子学、分子电子学、催化、分离科学、纳米工程和纳米生物工程变得越来越重要