Template Oligomerization for the Replication of Precisely Defined Synthetic Macromolecules

这项研究的重点是使用精确定义的模板来生产具有精确分子量和组成的有机低聚物。刚性棒状低聚物模板将用于快速构建与模板长度相同的低聚物。单体将通过共价键连接到模板上，然后通过化学诱导齐聚得到超分子母子双链。父子双链的切割将产生保留母体模板特定长度信息的子体低聚物。提出了重复使用母体模板和子体模板作为新模板的方法，从而使整个过程在模板中具有催化作用，最终在生产能力上类似于聚合酶链式反应(PCR)。该项目可以大大简化精确定义的大分子结构的制备，目前只能通过繁琐的分步程序或多次分析分离来制备。通过这一奖项，有机和高分子化学项目支持了南卡罗来纳大学化学和生物化学系的詹姆斯·M·图尔博士的研究。图尔教授将专注于开发新的路线，以方便地构建具有精确分子量和组成的有机低聚物。这些精密的大分子系统在电子学、光子学、分子电子学、催化、分离科学、纳米工程和纳米生物工程中正变得越来越重要。

The focus of this research is the use of precisely defined templates for the production of organic oligomers of precise molecular weight and constitution. Rigid-rod oligomer templates will be used for the rapid construction of oligomers having the same length as the templates. Monomers will be attached to the templates via covalent bonds, then oligomerization will be chemically induced to afford a supramolecular parent-daughter duplex. Cleavage of the parent-daughter duplex would produce a daughter oligomer that retains the specific length information of the parent template. Methods are proposed to reuse the parent template and the daughter as a new template, thus making the entire process catalytic in template, and ultimately similar to the polymerase chain reaction (PCR) in its productive capabilities. The project could significantly simplify the preparation of precisely defined macromolecular architectures which are currently prepared only by laborious step-wise procedures or multiple analytical separations. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. James M. Tour of the Department of Chemistry and Biochemistry at the University of South Carolina. Professor Tour will focus his work on developing new routes for the facile construction of organic oligomers of precise molecular weight and constitution. These precise macromolecular systems are becoming important for electronics, photonics, molecular electronics, catalysis, separation science, nano-engineering, and nano-bioengineering