Synthesis, Fluorescence Imaging and Tracking of Inherently Fluorescent Single-Molecule Nanocars

固有荧光单分子纳米汽车的合成、荧光成像和追踪

• 批准号: 1007483
• 负责人: James Tour
• 金额: $ 79万
• 依托单位: William Marsh Rice University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1007483&HistoricalAwards=false
• 关键词: Synthesis; Fluorescence; Imaging; Tracking; Inherently

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, James Tour, Stephan Link and Angel Marti of the William Marsh Rice University will develop and study molecules that exhibit controlled motion on a surface, "nanocars". The approach is to synthesize "nanocars" that incorporate fluorescent moieties within their frameworks and to continue expanding the repertoire of molecular parts that can be used to build these molecules. The PIs will also incorporate molecular entities into the "nanocars" that exhibit photon driven rotation and may acts as a propulsion mechanism for the molecules. Finally, the PIs will develop optical microscopy methods for tracking and characterizing the translation motion of the individual molecules and to utilize these methods to measure quantities such as collision frequencies and diffusion coefficients. The broader impacts involve training undergraduate students, graduate students and postdoctoral researchers. Additionally, the PIs plan to develop informal science learning approaches aimed at middle school students. Major principles in book chapters from middle school science curricula will be translated into bullet points, developed into dance songs (with professional help) and then added to open source Step Mania and Jamming software packages. This work will enhance our fundamental understanding about controlling individual molecular movement across a surface. Ultimately, such work could lead to the development of molecular machines that could control chemical transport and fabrication at ultrasmall dimensions.

在这个由化学系的大分子，超分子和纳米化学计划资助的项目中，威廉马什赖斯大学的James Tour，Stephan Link和Angel Marti将开发和研究在表面上显示受控运动的分子，“纳米汽车”。 该方法是合成“纳米汽车”，将荧光部分纳入其框架内，并继续扩大可用于构建这些分子的分子部分的库。 PI还将分子实体结合到“纳米汽车”中，其表现出光子驱动的旋转，并且可以充当分子的推进机制。 最后，PI将开发光学显微镜方法，用于跟踪和表征单个分子的平移运动，并利用这些方法测量碰撞频率和扩散系数等数量。 更广泛的影响包括培训本科生、研究生和博士后研究人员。 此外，PI计划开发针对中学生的非正式科学学习方法。 中学科学课程中书籍章节的主要原则将被翻译成要点，开发成舞蹈歌曲（在专业帮助下），然后添加到开源Step Mania和Jamming软件包中。 这项工作将增强我们对控制单个分子在表面上运动的基本理解。 最终，这些工作可能会导致分子机器的发展，这些机器可以控制超小尺寸的化学传输和制造。