Synthesis of Precise Unnatural Oligomers Using Well-Defined Synthetic or DNA Templates

使用明确的合成或 DNA 模板合成精确的非天然低聚物

• 批准号: 9612172
• 负责人: James Tour
• 金额: $ 5万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9612172&HistoricalAwards=false
• 关键词: Synthesis; Precise; Unnatural; Oligomers; Using

9612172 Tour New routes are described for the facile construction of organic oligomers of precise molecular weight, constitution, and in some cases, even stereochemistry, using unnatural and natural (DNA) templates (parents) of specific length, constitution, and conformation. Taking advantage of precisely-defined synthetic templates that are rigid-rod- like, the rapid construction of oligomers of nearly the same length as the templates will be attempted. Unnatural monomers will be ionically- or hydrogen-bonded to the templates via non-covalent bonding moieties (NCBMs), then oligomerization will be induced chemically or photochemically to afford a supramolecular parent-daughter duplex. The polymerizations should be kinetically favored since the templated reaction is pseudo-solid state or pseudo- topochemical in its monomer-monomer orientations. Cleavage of the ionically- or H-bound parent-daughter duplex would afford a new synthetic daughter oligomer that retains the specific length information of the parent template, as well as, possibly, the stereochemical information such as the helical sense. Methods can be envisioned to re-use the parent template and the daughter(s) as new templates, thus making the entire process catalytic in template, and ultimately natural-like or polymerase chain reaction-like (PCR-like) in its productive capabilities. %%% These precise macromolecular systems are becoming important for electronics, photonics, molecular electronics, catalysis, separation science, nano-engineering, and nano- bioengineering. This project, if successful, could significantly simplify the preparation of precisely defined macromolecular architectures which are currently prepared only by laborious step-wise procedures or multiple analytical separations. ***

9612172 Tour新路线描述了使用具有特定长度、构造和构象的非天然和天然（DNA）模板（亲本），轻松构建具有精确分子量、构造和在某些情况下甚至立体化学的有机低聚物。 利用精确定义的刚性棒状合成模板，将尝试快速构建与模板长度几乎相同的低聚物。 非天然单体将通过非共价键合部分（NCBM）离子键合或氢键合到模板上，然后将通过化学或光化学诱导寡聚化以提供超分子亲本-子代双链体。 聚合应该是动力学上有利的，因为模板化反应在其单体-单体取向上是假固态或假局部化学的。 离子或H结合的亲本-子代双链体的切割将提供新的合成子代寡聚体，其保留亲本模板的特定长度信息，以及可能的立体化学信息，如螺旋义。 可以设想重新使用母模板和子模板作为新模板的方法，从而使整个过程在模板中具有催化性，并最终在其生产能力中具有天然样或聚合酶链式反应样（PCR样）。 这些精确的大分子系统对于电子学、光子学、分子电子学、催化、分离科学、纳米工程和纳米生物工程变得越来越重要。 该项目如果成功，可以显着简化精确定义的大分子结构的制备，这些大分子结构目前仅通过费力的分步程序或多个分析分离来制备。 ***