Synthesis of Precise Unnatural Oligomers Using Well-Defined Synthetic or DNA Templates

使用明确的合成或 DNA 模板合成精确的非天然低聚物

• 批准号: 9612172
• 负责人: James Tour
• 金额: $ 5万
• 依托单位: University of South Carolina at Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9612172&HistoricalAwards=false
• 关键词: Synthesis; Precise; Unnatural; Oligomers; Using

9612172 Tour New routes are described for the facile construction of organic oligomers of precise molecular weight, constitution, and in some cases, even stereochemistry, using unnatural and natural (DNA) templates (parents) of specific length, constitution, and conformation. Taking advantage of precisely-defined synthetic templates that are rigid-rod- like, the rapid construction of oligomers of nearly the same length as the templates will be attempted. Unnatural monomers will be ionically- or hydrogen-bonded to the templates via non-covalent bonding moieties (NCBMs), then oligomerization will be induced chemically or photochemically to afford a supramolecular parent-daughter duplex. The polymerizations should be kinetically favored since the templated reaction is pseudo-solid state or pseudo- topochemical in its monomer-monomer orientations. Cleavage of the ionically- or H-bound parent-daughter duplex would afford a new synthetic daughter oligomer that retains the specific length information of the parent template, as well as, possibly, the stereochemical information such as the helical sense. Methods can be envisioned to re-use the parent template and the daughter(s) as new templates, thus making the entire process catalytic in template, and ultimately natural-like or polymerase chain reaction-like (PCR-like) in its productive capabilities. %%% These precise macromolecular systems are becoming important for electronics, photonics, molecular electronics, catalysis, separation science, nano-engineering, and nano- bioengineering. This project, if successful, could significantly simplify the preparation of precisely defined macromolecular architectures which are currently prepared only by laborious step-wise procedures or multiple analytical separations. ***

9612172游览新路线是为精确分子重量，宪法的有机低聚物的便利构造所描述的，在某些情况下，甚至使用特定长度，宪法和构象的不自然和天然（父母）模板（父母）（父母）模板（父母）（父母）和构象。 利用刚性刚性的精确定义的合成模板，将尝试尝试与模板的快速构造几乎相同的长度。 不自然的单体将通过非共价键合部分（NCBMS）在离子上或氢键合，然后将寡聚化在化学或光化学上诱导，以提供超分子的父母双重狗狗。 由于模板反应是伪固态状态或伪拓制化学的单体知识分子方向，因此应在动力学上偏爱聚合。 在离子或H绑定的父母双链双链双链的裂解中，将提供一种新的合成子寡聚物，该低聚物保留了父模板的特定长度信息，以及可能的立体化学信息，例如螺旋感。 可以设想将方法重新使用母体模板和女儿作为新模板，从而使整个过程催化模板中的整个过程催化，并最终在其生产能力中以类似天然的或聚合酶链的反应（PCR样）。 这些精确的大分子系统对于电子，光子学，分子电子，催化，分离科学，纳米工程和纳米生物工程变得重要。 如果成功的话，该项目可以大大简化精确定义的大分子体系结构的制备，这些结构目前仅通过费力的阶梯程序或多个分析分离来制备。 ***