Biomolecular and Engineering Studies of Extremely Thermophilic Xylose (Glucose) Isomerases

极高温木糖（葡萄糖）异构酶的生物分子和工程研究

• 批准号: 9809964
• 负责人: J. Gregory Zeikus
• 金额: $ 26.7万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9809964&HistoricalAwards=false
• 关键词: Biomolecular; Engineering; Studies; Extremely; Thermophilic

9809964 Zeikus This project is to investigate: 1) mechanisms responsible for enzyme thermal and acid stability; 2) structural features that control enzyme activity, substrate specificity, and cofactor specificity; 3) new xylose isomerases with different activities and thermo-acid stabilities; 4) strategies for creating thermo-acid-stable enzymes and catalytically improved xylose isomerases for high fructose corn syrup production; and 5) knowledge about the performance of immobilized high temperature enzymes. The interaction between engineering and biochemistry students provided by this project is to be an excellent preparation for their future participation in the expanding fields of bioprocesing and biotechnology. ***

9809964 Zeikus本项目将研究：1)控制酶活性、底物专一性和辅因子专一性的结构特征；3)具有不同活性和热酸稳定性的新木糖异构酶；4)创造耐热酸稳定酶和催化改进的木糖异构酶以生产高果糖玉米糖浆的策略；2)控制酶活性、底物专一性和辅因子专一性的结构特征；以及5)关于固定化高温酶性能的知识。这个项目提供的工程学和生物化学学生之间的互动是为他们未来参与不断扩大的生物加工和生物技术领域的极好的准备。***