Biomolecular and Engineering Studies of Extremely Thermophilic Xylose (Glucose) Isomerases

[809964] Zeikus本项目主要研究：1)酶的热稳定性和酸稳定性机制；2)控制酶活性、底物特异性和辅因子特异性的结构特征；3)具有不同活性和热酸稳定性的新型木糖异构酶；4)制备高果糖玉米糖浆用热酸稳定酶和催化改进木糖异构酶的策略；5)固定化高温酶的性能知识。这个项目提供了工程和生物化学学生之间的互动，为他们将来参与不断扩大的生物加工和生物技术领域做了很好的准备。＊＊＊

9809964 Zeikus This project is to investigate: 1) mechanisms responsible for enzyme thermal and acid stability; 2) structural features that control enzyme activity, substrate specificity, and cofactor specificity; 3) new xylose isomerases with different activities and thermo-acid stabilities; 4) strategies for creating thermo-acid-stable enzymes and catalytically improved xylose isomerases for high fructose corn syrup production; and 5) knowledge about the performance of immobilized high temperature enzymes. The interaction between engineering and biochemistry students provided by this project is to be an excellent preparation for their future participation in the expanding fields of bioprocesing and biotechnology. ***