An Integrated Environment for Reasoning about regulatory Control elements in Microbial genomes

用于推理微生物基因组中调控元件的集成环境

• 批准号: 9810537
• 负责人: Theresa Gaasterland
• 金额: $ 5万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-06-10
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9810537&HistoricalAwards=false
• 关键词: Integrated; Environment; Reasoning; about; regulatory

IRI-9810537Gaasterland, Theresa [e-mail] of Chicago$0 - 18 mos. (Jointly funded with the CISE Institutional Infrastructure - Total Award $49,998)CONACyT: An Integrated Environment for Reasoning about Regulatory ControlElements in Microbial GenomesThis research is a collaboration of the PI with Dr. Julio Collado-Vides in Mexico. The goal is to use artificial intelligence techniques in deciphering patterns of conservation of regulatory elements across whole bacterial genomes by integrating two different platforms for investigating genomes: a multi-genome annotation tool that uses automated reasoning and cooperative answering methods to associate features with a genomic sequence (the already existing MAGPIE system, developed by Gaasterland) and a database of regulatory elements, operons, and related regulatory signals encoded in E. coli genomic DNA (Regulon DB, assembled by Collado-Vides). To do this, new methods need to be developed for the combination of different types of knowledge to make predictions, and the system must be able to revise prior predictions based on new knowledge. In addition, there will be insights into appropriate knowledge representations that capture bothstructure and function of living organisms. On the biological side, the infrastructure developed in the project will enable an understanding of the degree to which knowledge gained from one organism can be used to guide the exploration of a new organism.http://www.cs.uchicago.edu/~gaasterl/

IRI-9810537Gaasterland, Theresa [e-mail] 芝加哥大学$0 - 18 个月。 （与 CISE 机构基础设施共同资助 - 总奖金 49,998 美元）CONACyT：用于推理微生物基因组中监管控制元素的综合环境这项研究是 PI 与墨西哥 Julio Collado-Vides 博士的合作项目。 目标是通过集成两个不同的基因组研究平台，使用人工智能技术破译整个细菌基因组中调控元件的保守模式：一个多基因组注释工具，使用自动推理和协作应答方法将特征与基因组序列关联起来（已经存在的 MAGPIE 系统，由 Gaasterland 开发）和一个调控元件、操纵子和相关基因的数据库。 大肠杆菌基因组 DNA 中编码的调节信号（Regulon DB，由 Collado-Vides 组装）。为此，需要开发新的方法来组合不同类型的知识来进行预测，并且系统必须能够根据新知识修正先前的预测。 此外，还将深入了解捕捉生物体结构和功能的适当知识表示。 在生物学方面，该项目开发的基础设施将有助于了解从一种生物体获得的知识可以在多大程度上用于指导新生物体的探索。http://www.cs.uchicago.edu/~gaasterl/