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Neural mechanisms of processing emotional information from faces and voices in social phobia

处理社交恐惧症中面部和声音情绪信息的神经机制

基本信息

批准号：
127754135
负责人：
Professor Dr. Wolfgang Miltner
金额：
--
依托单位：
Institut für Medizinische Psychologie und Systemneurowissenschaften
依托单位国家：
德国
项目类别：
Research Units
财政年份：
2009
资助国家：
德国
起止时间：
2008-12-31 至 2016-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/127754135?language=en
关键词：
Neural mechanisms processing emotional information

项目摘要

Patients suffering from social phobia show information processing biases and increased brain responses during the processing of socially threatening stimuli, such as angry faces and prosody. However, it is unknown to what extent automatic brain responses to social threat signals in social phobia depend on cognitive resources, threat-relevance, modality and intensity of emotional social stimuli and whether brain responses can be modified by successful psychotherapy, such as cognitive-behavioural therapy (CBT). Based on stimuli, methods and results from the first funding period, the current project extends the research questions into the clinical domain. The aim is to investigate brain activation during automatic processing of emotional facial expressions and prosody in social phobia before and after CBT. Using parallel event-related functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) and by means of the variation of emotional expression (angry, happy, neutral), emotional intensity (low, high), attentional load (low, high) and sensory modality (faces, voices), we intend to answer the following questions. (1) Is there evidence for rapid threat-specific brain responses to faces and voices in social phobia? (2) Which role does attentional load play for emotion-specific activation patterns? (3) Are there overlapping/similar brain mechanisms for processing emotional information from voices and faces in social phobia? (4) How are phobia-related automatic brain responses modified by successful CBT? (5) Do brain responses during automatic processing of social stimuli predict treatment responses?

患有社交恐惧症的患者在处理社交威胁刺激（如愤怒的面孔和韵律）时表现出信息处理偏见和增加的大脑反应。然而，目前尚不清楚社交恐惧症患者对社交威胁信号的自动大脑反应在多大程度上取决于认知资源、威胁相关性、情感社交刺激的方式和强度，以及大脑反应是否可以通过成功的心理治疗（如认知行为治疗）来改变。基于第一个资助期的刺激，方法和结果，目前的项目将研究问题扩展到临床领域。本研究旨在探讨社交恐惧症患者在认知行为治疗前后情绪面部表情和韵律自动加工过程中的脑激活。本研究采用平行事件相关功能磁共振成像（fMRI）和脑电图（EEG）技术，通过情绪表达（愤怒、高兴、中性）、情绪强度（低、高）、注意负荷（低、高）和感觉通道（面孔、声音）的变化来回答以下问题。(1)是否有证据表明社交恐惧症患者的大脑对面孔和声音的快速威胁特异性反应？(2)注意负荷在情绪激活模式中扮演什么角色？(3)在社交恐惧症中，是否存在重叠/相似的大脑机制来处理来自声音和面孔的情感信息？(4)成功的CBT如何修改与恐惧症相关的自动大脑反应？(5)大脑在自动处理社会刺激时的反应能预测治疗反应吗？