Emotional processing following insula lesion

岛叶损伤后的情绪处理

• 批准号: 262220369
• 负责人: Professor Dr. Wolfgang Miltner
• 金额: --
• 依托单位: Institut für Medizinische Psychologie und Systemneurowissenschaften
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/262220369?language=en
• 关键词: Emotional; processing; following; insula; lesion

A growing number of brain imaging studies have demonstrated the association of insular cortex activation with aspects of emotional processing. These findings support theoretical models of the insula as a prominent component of emotional experience and perception of emotions, primarily by representing interoceptive body information. Up to now there are only a few single case reports of patients with insula lesions that are confirming the imaging data. The objective of the present series of investigations is to examine the role of the insular cortex in emotional processing within the current theoretical framework. By means of a large sample size, a multimodal assessment of emotional processing with respect to physiological indicators of emotional states, structural and functional imaging techniques we want to examine the specifity of deficits in emotional perception and experience. Moreover, the impact of size and location of the lesion (right vs. left hemisphere, anterior vs. posterior) and the role of functional reorganization will be elucidated. Thus, the cohort will consist of at least 30 stroke patients suffering from lesions of the right or left insular cortex, as well as patients with other lesion locations and 30 healthy controls.

越来越多的脑成像研究表明，岛叶皮层的激活与情绪处理的各个方面有关。这些发现支持了脑岛作为情绪体验和情绪感知的重要组成部分的理论模型，主要是通过代表内感受性身体信息。到目前为止，只有少数病例报告证实了影像学数据。本系列研究的目的是在当前的理论框架内研究岛叶皮层在情绪处理中的作用。通过大量的样本，对情绪状态的生理指标，结构和功能成像技术进行情绪处理的多模态评估，我们想要检查情绪感知和经验缺陷的特异性。此外，将阐明病变的大小和位置（右半球与左半球，前半球与后半球）的影响以及功能重组的作用。因此，该队列将包括至少30名患有右侧或左侧岛皮质病变的中风患者，以及其他病变部位的患者和30名健康对照者。

项目成果

Lateralized Deficits of Disgust Processing After Insula-Basal Ganglia Damage

• DOI: 10.3389/fpsyg.2020.01429
• 发表时间: 2020-06-30
• 期刊: FRONTIERS IN PSYCHOLOGY
• 影响因子: 3.8
• 作者: Holtmann, Olga;Bruchmann, Maximilian;Straube, Thomas
• 通讯作者: Straube, Thomas

Lateralized deficits in arousal processing after insula lesions: Behavioral and autonomic evidence

岛叶损伤后唤醒处理的偏侧化缺陷：行为和自主神经证据

• DOI: 10.1101/2021.03.24.436828
• 发表时间: 2021
• 期刊: Cortex
• 影响因子: 3.6
• 作者: Holtmann O;Franz M;Moenig C;Tenberge J.-G;Schloßmacher I;Ivanova I;Preul C;Schwindt W;Melzer N;Miltner W. H. R;Straube T.
• 通讯作者: Straube T.