SGER: Microfabricated Microneedles: Feasibility Studies of Transdermal Insulin Delivery

9813321 Prausnitz这项研究的目的是测试一种新的经皮给药方法，包括使用标准的微加工技术将微米尺寸的针阵列蚀刻到硅中。 微针的设计，无痛渗透皮肤，是基于对皮肤解剖学的理解。 微针穿透皮肤略大于10-15微米，应该提供穿过角质层的传输路径，但是这样做是无痛的，因为微针不会到达在更深组织中发现的神经。 为了使这种技术适用于透皮给药，研究人员提出创建长度为100微米量级的尖端尖锐的微针的三维阵列。 因为皮肤表面不是平坦的，所以这些微针的全长不会穿透皮肤。 微加工技术可以根据无痛分娩的需要进行修改，以制造更长或更短的针头。

9813321PrausnitzThe goal of this proposed research is to test a novel approach to transdermal drug delivery involving the use of standard microfabrication techniques to etch arrays of micron-size needles into silicon. The design of microneedles, which painlessly permeabilize the skin, is based on an understanding of skin anatomy. Microneedles, which penetrate the skin a little more than 10-15 microns, should provide transport pathways across the stratum corneum, but do so painlessly since the microneedles do not reach the nerves found in deeper tissue. To adapt this technilogy for transdermal drug delivery, the investigator proposes creating three-dimensional arrays of sharp-tipped microneedles on the order of 100 microns in length. Because the skin surface is not flat, the full length of these microneedles will not penetrate the skin. The microfabrication technique can be modified to make longer or shorter needles as required for painless delivery.