Microfabricated all-diamond microelectrode arrays for neurotransmitter sensing and extracellular recording

用于神经递质传感和细胞外记录的微加工全金刚石微电极阵列

基本信息

  • 批准号:
    10337137
  • 负责人:
  • 金额:
    $ 61.75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-04-01 至 2025-01-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Complete understanding of brain function requires reliable and comprehensive mapping of large-scale brain networks with high spatiotemporal resolution and minimum invasiveness. Tools to achieve such mapping must overcome a myriad of challenges that are not adequately or simultaneously addressed by any existing technology. Hence the overall goal of this proposal is to develop a new diamond-based neural interface system that consists of up to 256 recording sites in mm3-sized volumes for combined electrical and chemical detection of neuronal activity in living nerve tissues. The proposed innovative tool will have the following significant advantages over existing technologies. First, highly-conductive BDD electrodes will simultaneously enhance the sensitivity, selectivity, and stability of neurological sensing. They will also have a greater potential range of operation than current electrode materials. Second, by using undoped PCD as a hermetic, biocompatible, and low-fouling encapsulation material, the new device will potentially have greater longevity and long-term stability for chronic applications. Third, a compact, dual-mode headstage will better enable the control of electrophysiology and fast-scan cyclic voltammetric (FSCV) measurements with high precision and a strong signal-to-noise ratio, while minimizing crosstalk. Fourth, the novel micromachining technique will permit wafer-level, mass production of diamond electrodes with various geometries, fine spatial resolution (submicrometer to micrometer scale), and high yields (>90%). Adopted from well-established semiconductor manufacturing techniques, the proposed fabrication approach is more reliable, consistent, scalable, and labor/cost-efficient than the hand assembly approach that is widely used today for making carbon fiber electrodes. Last but not least, 3D arrays of highly packed electrodes will significantly enhance the lateral and depth coverage of the new electrochemical detection tools compared to current chemical sensing tools. The project will be conducted by a multidisciplinary, collaborative team of researchers. The team will leverage their extensive experience in developing diamond fiber electrodes and in refining material synthesis and device fabrication techniques to push the spatial resolution of diamond electrodes from several tens of microns to submicrometer (via electron-beam lithography) and to micrometer (via ultraviolet lithography) (Aim 1). In parallel with electrode development, the team will engineer solutions to implement miniaturized head-mounted electrophysiology and FSCV electronics, and integrate the headstage with diamond electrode arrays to achieve a complete system (Aim 2). The functionality, biocompatibility, and stability of the integrated system will then be assessed ex vivo and in vivo using complementary analysis techniques (Aim 3). The proposed work is significant because it will yield a revolutionary neural interface tool that can be readily disseminated to other researchers for use in neuroscience and clinical studies to reveal the mechanisms underlying many brain disorders and diseases.
项目总结

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Wen Li其他文献

Wen Li的其他文献

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{{ truncateString('Wen Li', 18)}}的其他基金

Placental barrier culture to delineate the mechanism of hepatitis E virus infection at the maternal and fetal interface
胎盘屏障培养描绘母体和胎儿界面戊型肝炎病毒感染的机制
  • 批准号:
    10716971
  • 财政年份:
    2023
  • 资助金额:
    $ 61.75万
  • 项目类别:
A Neurosensory Account of Posttraumatic Stress Disorder
创伤后应激障碍的神经感觉学解释
  • 批准号:
    10607183
  • 财政年份:
    2023
  • 资助金额:
    $ 61.75万
  • 项目类别:
Deficient inhibition underlies salience network hyperactivity in stress and anxiety
抑制不足是压力和焦虑中显着网络过度活跃的基础
  • 批准号:
    10377665
  • 财政年份:
    2022
  • 资助金额:
    $ 61.75万
  • 项目类别:
Deficient inhibition underlies salience network hyperactivity in stress and anxiety
抑制不足是压力和焦虑中显着网络过度活跃的基础
  • 批准号:
    10559649
  • 财政年份:
    2022
  • 资助金额:
    $ 61.75万
  • 项目类别:
Microfabricated all-diamond microelectrode arrays for neurotransmitter sensing and extracellular recording
用于神经递质传感和细胞外记录的微加工全金刚石微电极阵列
  • 批准号:
    10563205
  • 财政年份:
    2020
  • 资助金额:
    $ 61.75万
  • 项目类别:
Strategy for combining circulating tumor DNA (ctDNA) and magnetic resonance imaging (MRI) measures of tumor burden for prediction of response and outcome in neoadjuvant-treated early breast cancer
结合循环肿瘤 DNA (ctDNA) 和肿瘤负荷磁共振成像 (MRI) 测量来预测新辅助治疗的早期乳腺癌的反应和结果的策略
  • 批准号:
    10311505
  • 财政年份:
    2020
  • 资助金额:
    $ 61.75万
  • 项目类别:
Strategy for combining circulating tumor DNA (ctDNA) and magnetic resonance imaging (MRI) measures of tumor burden for prediction of response and outcome in neoadjuvant-treated early breast cancer
结合循环肿瘤 DNA (ctDNA) 和肿瘤负荷磁共振成像 (MRI) 测量来预测新辅助治疗的早期乳腺癌的反应和结果的策略
  • 批准号:
    10523117
  • 财政年份:
    2020
  • 资助金额:
    $ 61.75万
  • 项目类别:
Enhancing CNS Drug Delivery By Manipulating The Blood-Brain Barrier
通过操纵血脑屏障增强中枢神经系统药物输送
  • 批准号:
    8384079
  • 财政年份:
    2012
  • 资助金额:
    $ 61.75万
  • 项目类别:
Sensory Perception of Threat in Anxiety
焦虑中对威胁的感官知觉
  • 批准号:
    8293586
  • 财政年份:
    2012
  • 资助金额:
    $ 61.75万
  • 项目类别:
Sensory Perception of Threat in Anxiety
焦虑中对威胁的感官知觉
  • 批准号:
    8608006
  • 财政年份:
    2012
  • 资助金额:
    $ 61.75万
  • 项目类别:

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