Heterogeneities and Avalanches in Lung Mechanics: Crackle Sound and Artificial Ventilation

肺力学的异质性和雪崩：爆裂声和人工通气

• 批准号: 9813599
• 负责人: Bela Suki
• 金额: $ 52.99万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9813599&HistoricalAwards=false
• 关键词: Heterogeneities; Avalanches; Lung; Mechanics; Crackle

9813599SukiThe objective of this research is to expand on the investigators earlier discovery of "avalanching" in airway opening during inspiration/ventilation. The investigator discovered that an airway will open when the inflation pressure exceeds the critical opening threshold pressure. The random spatial distribution of the critical opening threshold pressure causes multiple airway openings for a given increase in airway pressure. This essentially causes the avalanche effect. This research seeks to: (1) continue to study heterogeneity of structure and function in airway opening, (2) to study dynamics of lung sounds, and (3) develop improved variable ventilation strategies for mechanical ventilation based on a stochastic resonance model.***

9813599 suki本研究的目的是扩展研究者早期发现的吸气/通气时气道开口的“雪崩”。研究者发现，当充气压力超过临界开启阈值压力时，气道会打开。临界开启阈值压力的随机空间分布导致气道压力给定增加时出现多个气道开启。这就导致了雪崩效应。本研究旨在：(1)继续研究气道开放结构和功能的异质性；(2)研究肺音的动力学；(3)基于随机共振模型开发改进的机械通气可变通气策略