Lung Structure-Function in Mice via Acoustic Morphotometry

通过声学形态测量法研究小鼠肺的结构-功能

• 批准号: 0402530
• 负责人: Bela Suki
• 金额: $ 29.16万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0402530&HistoricalAwards=false
• 关键词: Lung; Structure; Function; Mice; via

0402530SukiThe main goals of this proposal are a) to develop a coherent technology that allows theassessment of the detailed physiological functioning as well as the structure of the mouse lung in a noninvasive manner, and b) to invoke these technologies to advance fundamental relations between molecular processes altering tissue composition of the emphysematous lung and degradation in function. The specific aims are:1) To develop a method to assess and relate the structure and function of the mouse lung in a non-invasive manner.2) To test the methods in normal, fibrotic and emphysematous lungs following pharmacological interventions.3) To track, on an individual basis, the alterations in structure and function in a genetically modified mouse strain that develops spontaneous emphysema.

0402530 Suki该提案的主要目标是a）开发一种连贯的技术，允许以非侵入性方式评估小鼠肺的详细生理功能以及结构，和B）调用这些技术来推进改变肺气肿肺的组织组成和功能退化的分子过程之间的基本关系。具体目标是：1）开发一种以非侵入性方式评估和关联小鼠肺的结构和功能的方法。2）在药物干预后在正常、纤维化和肺气肿肺中测试该方法。3）在个体基础上跟踪发生自发性肺气肿的转基因小鼠品系中结构和功能的改变。