New Insights Into Lung Structure and Function Through Acoustic Morphometry

通过声学形态测量对肺结构和功能的新见解

• 批准号: 0114538
• 负责人: Bela Suki
• 金额: $ 58.76万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0114538&HistoricalAwards=false
• 关键词: New; Insights; Into; Lung; Structure

0114538SukiThe objective of this research is to extract information about the structure and function of the lung from noninvasive acoustic measurements. The specific aims of this research are: (1) to measure sound waves produced during airway opening (crackle sound) and the lung pressure-volume (P-V) curve in normal and surfactant depleted lungs from several species with distinctly different airway geometry, (2) to analyze the airway structure from the crackle sound and the P-V curve and compare it to available morphometric data, and (3) to use airway tree models to predict the relationships between lung mechanics, lung function including Computed Tomography images, and the mechanism of lung injury during mechanical ventilation.

[01:14 . 538]本研究的目的是从无创声学测量中提取有关肺结构和功能的信息。本研究的具体目的是：(1)测量几种具有明显不同气道几何形状的正常和缺乏表面活性剂的肺在气道打开时产生的声波（裂纹声）和肺压力-体积（P-V）曲线；(2)从裂纹声和P-V曲线分析气道结构，并将其与现有的形态测量数据进行比较；(3)使用气道树模型预测肺力学、肺功能（包括计算机断层扫描图像）之间的关系；探讨机械通气过程中肺损伤的机制。