Small Ring-Mediated Organic Synthesis

小环介导的有机合成

• 批准号: 9813975
• 负责人: Jin Cha
• 金额: $ 27.24万
• 依托单位: University of Alabama Tuscaloosa
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9813975&HistoricalAwards=false
• 关键词: Small; Ring; Mediated; Organic; Synthesis

The focus of this research is the use of a variant of the Kulinkovich cyclopropanation reaction to afford hetero-substituted cyclopropanes. The substituted cyclopropanes will serve as synthetic intermediates for the production of several classes of organic compounds. Among the target molecules are medium sized carbocycles, triquinanes and functionalized alkaloids.With this new award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Jin K. Cha of the Department of Chemistry at the University of Alabama. Professor Cha will focus his work on developing synthetic methodology which relies on the inherent reactivity of three membered rings. The methodology will be used to synthesize interesting natural products.

本研究的重点是利用库林科维奇环丙烷化反应的一种变体来合成杂环丙烷。取代的环丙烷将作为合成中间体，用于生产几类有机化合物。在目标分子中有中等大小的碳环、三喹烷和官能化生物碱。有了这个新的奖项，有机和高分子化学计划支持阿拉巴马大学化学系的金·K·查博士的研究。查教授将专注于开发合成方法，这种方法依赖于三元环的内在反应性。该方法将用于合成有趣的天然产品。