Cross-Coupling of Alkenes via Titanacyclopropanes

该奖将资助韦恩州立大学化学系的Jin K. Cha教授探索钛环丙烷中间体（Kulinkovich试剂）在有机合成中的应用。特别强调的是由环丙醇生成金属酮同烯醇酯，以及随后的交叉偶联反应。这些路线为现有方法提供了有吸引力的替代方案，因为高收敛性可以实现分段耦合。此外，所需的试剂价格低廉，对环境无害。拟议的研究涉及开发C-C键形成的使能技术，用于制备可用于化学和制药工业，材料科学和生物学的有用化合物，因此具有广泛的科学影响的潜力。更广泛的教育影响在于培养合成化学家，以期为未来的科学劳动力做出贡献。

With this award the Chemical Synthesis Program of the Chemistry Division is funding Professor Jin K. Cha of the Department of Chemistry at Wayne State University to explore the utility of the titanacyclopropane intermediates (Kulinkovich reagent) in organic synthesis. Particular emphasis is placed at the generation of metal keto homoenolates from cyclopropanols, along with subsequent cross-coupling reactions. These routes offer attractive alternatives to existing methods, as high convergency is possible to achieve segment coupling. Additionally, the requisite reagents are inexpensive and environmentally benign.The proposed study involves the development of enabling technology in C-C bond formation for the preparation of useful compounds that can be used in the chemical and pharmaceutical industry, materials science and biology, and hence has potential for broad scientific impact. The educational broader impact lies in the training of synthetic chemists expected to contribute to the future workforce in science.