Cross-Coupling of Alkenes via Titanacyclopropanes

通过二环丙烷进行烯烃交叉偶联

• 批准号: 1212879
• 负责人: Jin Cha
• 金额: $ 14.5万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1212879&HistoricalAwards=false
• 关键词: Cross; Coupling; Alkenes; via; Titanacyclopropanes

With this award the Chemical Synthesis Program of the Chemistry Division is funding Professor Jin K. Cha of the Department of Chemistry at Wayne State University to explore the utility of the titanacyclopropane intermediates (Kulinkovich reagent) in organic synthesis. Particular emphasis is placed at the generation of metal keto homoenolates from cyclopropanols, along with subsequent cross-coupling reactions. These routes offer attractive alternatives to existing methods, as high convergency is possible to achieve segment coupling. Additionally, the requisite reagents are inexpensive and environmentally benign.The proposed study involves the development of enabling technology in C-C bond formation for the preparation of useful compounds that can be used in the chemical and pharmaceutical industry, materials science and biology, and hence has potential for broad scientific impact. The educational broader impact lies in the training of synthetic chemists expected to contribute to the future workforce in science.

化学系的化学合成计划将资助金K教授获得该奖项。韦恩州立大学化学系的Cha研究了钛环丙烷中间体（Kulinkovich试剂）在有机合成中的应用。 特别强调的是放在金属酮homoenolates从环丙醇，沿着与随后的交叉偶联反应的产生。 这些路线提供了有吸引力的替代现有的方法，因为高收敛性是可能实现段耦合。 此外，所需试剂价格低廉，对环境无害，拟议的研究涉及开发C-C键形成的使能技术，以制备可用于化学和制药工业、材料科学和生物学的有用化合物，因此具有广泛的科学影响潜力。 更广泛的教育影响在于合成化学家的培训，预计将有助于未来的科学劳动力。