Metal-Oxo and Metal-Peroxo Intermediates in Oxidative Catalysis

这个奖项在无机，生物无机和有机化学计划支持研究仿生氧化机制的博士约翰T。普林斯顿大学化学系的格罗夫斯。 将研究五种类型的反应：氧化和过氧金属配合物的氧化;钌卟啉的催化氧化;一氧化二氮的烃氧化;不对称氧化的催化剂;和非血红素二铁催化剂的烃氧化。 这些反应的机理将详细研究使用快速动力学技术，包括快速混合方法，顺磁NMR弛豫，和同位素fractionation.Catalytic氧化烃类继续是基本的利益和潜在的巨大的经济价值，在化学过程industry。 了解潜在的机制，预计将导致重要的合成和工业有机化学的新方法，并提供重要的生化转化的见解。 开发一氧化二氮作为氧化剂将提供一种工业生态替代氧气，因为它将利用尼龙生产副产品产生的温室气体。

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research on biomimetic oxidation mechanisms by Dr. John T. Groves of the Chemistry Department, Princeton University. Five types of reactions will be investigated: oxidations by oxo- and peroxo-metal complexes; catalytic oxidation by ruthenium porphyrins; hydrocarbon oxygenation by nitrous oxide; catalysts for asymmetric oxygenation; and non-heme di-iron catalysts for oxidation of hydrocarbons. The mechanisms of these reactions will be studied in detail using fast kinetic techniques, including rapid-mixing methods, paramagnetic NMR relaxation, and isotopic fractionation.Catalytic oxygenation of hydrocarbons continues to be of fundamental interest and potentially of great economic value in the chemical process industry. Understanding the underlying mechanisms is expected to lead to new approaches to important synthetic and industrial organic chemistry, and also to offer insights into significant biochemical transformations. Development of nitrous oxide as an oxidant would offer an industrially ecological alternative to oxygen since it would utilize a greenhouse gas generated as a byproduct of nylon production.