SGER: Towards Active Membrane Transport Using Optically- Responsive and Electroactive Macromolecules

作者：vjohn at nsf18日期：7/8/98 9：19 AM优先级：正常至：Adthoma主题：9815482 Hillier-摘要-摘要建议编号：9815482建议书类型：SGER首席研究员：安德鲁·希利尔隶属关系：弗吉尼亚大学这项资助是通过界面的分离和纯化计划子元素授予的，化学和运输系统司的运输和分离计划。首席研究员是弗吉尼亚大学的安德鲁·希利尔博士。这项研究旨在开发一类具有结合特性的适应性材料，其结合特性可以响应当地环境的变化。这些材料在化学分离中特别有吸引力，因为它们的环境敏感性既可以用作分析物结合的信号，也可以用作主动控制化学亲和力的手段。具体地说，一系列超分子化合物将基于阳离子选择性聚醚和阴离子选择性聚氨的大环而被连接到氧化还原活性的茂金属或光学响应的重氮苯上。大环的化学亲和力将通过改变其化学组成和环大小来调整，以调整从卤化物到过渡金属等小的无机离子的选择性。在这些材料中，将研究光学电化学诱导的结合行为转换的影响。这些大分子的分离特性将在水溶液中被结合到液体和双层类脂膜中进行检测。这项工作提供了一类具有高度可控的化学结合行为的新型材料和一种可以外部触发的开关机制，以主动控制基于膜的分离过程，并设计出新型的化学传感技术。这项工作将导致新材料的发现和实施，这些材料为操纵化学亲和力和运输性质提供了一个特别受控的局部环境。

Author: vjohn at nsf18 Date: 7/8/98 9:19 AM Priority: Normal TO: adthomas Subject: 9815482 Hillier - Abstract ------------------------------- Message Contents ------------------------------- Abstract Proposal No: 9815482 Proposal Type: SGER Principal Investigator: Andrew Hillier Affiliation: University of Virginia This grant is awarded through the Separations and Purification Program sub-element of the Interfacial, Transport and Separations Program of the Chemical and Transport Systems Division. The principal investigator is Dr. Andrew Hillier at the University of Virginia. The research is directed towards the development of a class of adaptive materials whose binding characteristics respond to changes in their local environment. These materials are particularly attractive in chemical separation as their environmental sensitivity can be used as either a signal of analyte binding or as a means of actively controlling chemical affinity. Specifically, a series of supramolecular compounds will be constructed based on macrocylces of cation-selective polyethers and anion-selective polyammoniums that are tethered to redox-active metallocenes or optically-responsive diazobenzenes. The chemical affinity of the macrocycle will be tuned by varying its chemical composition and ring size to adjust selectivity for small, inorganic ions ranging from halides to transition metals. The impact of optically electrochemically-induced switching of the binding behavior in these materials will be investigated. The separation characteristics of these macromolecules will be examined in aqueous solutions while incorporated into liquid and bilayer lipid membranes. This work provides a novel class of materials with highly controllable chemical binding behavior and a switching mechanism that can be externally triggered to actively control membrane-based separation processes and design novel chemical sensing techniques. The work will lead to the discovery and implementation of new materials that provide a specifically controlled local environment for manipulation of chemical affinity and transport properties.