SGER: Towards Active Membrane Transport Using Optically- Responsive and Electroactive Macromolecules

作者：vjohn at nsf18日期：7/8/98 9:19 AM优先级：Normal TO: adthomas主题：9815482 Hillier -摘要-------------------------------消息内容-------------------------------摘要提案编号：9815482提案类型：SGER首席研究员：Andrew Hillier联系：该资助是通过化学和运输系统部界面、运输和分离项目的分离和净化项目子项目授予的。首席研究员是弗吉尼亚大学的安德鲁·希利尔博士。该研究旨在开发一类自适应材料，其结合特性响应其局部环境的变化。这些材料在化学分离中特别有吸引力，因为它们的环境敏感性既可以用作分析物结合的信号，也可以用作主动控制化学亲和力的手段。具体来说，一系列超分子化合物将基于阳离子选择性聚醚和阴离子选择性聚铵的大环构建，这些大环与氧化还原活性的茂金属或光学响应的重偶氮苯相连。大环的化学亲和性将通过改变其化学成分和环的大小来调节从卤化物到过渡金属的小无机离子的选择性。光电化学诱导开关对这些材料的结合行为的影响将被研究。这些大分子的分离特性将被检查在水溶液中，同时纳入液体和双层脂质膜。这项工作提供了一类具有高度可控化学结合行为和开关机制的新型材料，可以通过外部触发来主动控制基于膜的分离过程，并设计新的化学传感技术。这项工作将导致新材料的发现和实施，为化学亲和和运输性质的操纵提供一个特定的受控局部环境。

Author: vjohn at nsf18 Date: 7/8/98 9:19 AM Priority: Normal TO: adthomas Subject: 9815482 Hillier - Abstract ------------------------------- Message Contents ------------------------------- Abstract Proposal No: 9815482 Proposal Type: SGER Principal Investigator: Andrew Hillier Affiliation: University of Virginia This grant is awarded through the Separations and Purification Program sub-element of the Interfacial, Transport and Separations Program of the Chemical and Transport Systems Division. The principal investigator is Dr. Andrew Hillier at the University of Virginia. The research is directed towards the development of a class of adaptive materials whose binding characteristics respond to changes in their local environment. These materials are particularly attractive in chemical separation as their environmental sensitivity can be used as either a signal of analyte binding or as a means of actively controlling chemical affinity. Specifically, a series of supramolecular compounds will be constructed based on macrocylces of cation-selective polyethers and anion-selective polyammoniums that are tethered to redox-active metallocenes or optically-responsive diazobenzenes. The chemical affinity of the macrocycle will be tuned by varying its chemical composition and ring size to adjust selectivity for small, inorganic ions ranging from halides to transition metals. The impact of optically electrochemically-induced switching of the binding behavior in these materials will be investigated. The separation characteristics of these macromolecules will be examined in aqueous solutions while incorporated into liquid and bilayer lipid membranes. This work provides a novel class of materials with highly controllable chemical binding behavior and a switching mechanism that can be externally triggered to actively control membrane-based separation processes and design novel chemical sensing techniques. The work will lead to the discovery and implementation of new materials that provide a specifically controlled local environment for manipulation of chemical affinity and transport properties.