SGER: Towards Active Membrane Transport Using Optically- Responsive and Electroactive Macromolecules

作者：vjohn at nsf 18日期： 1998年7月8日9：19 AM优先级：正常收件人：adthomas主题：9815482 Hillier -摘要- 摘要 提案编号： 9815482 提案类型： SGER 主要研究者： 安德鲁·希利尔 所属单位： 弗吉尼亚大学 这项补助金是通过分离和纯化计划授予的 界面，运输和分离计划的子元素 化学和运输系统司。校长 弗吉尼亚大学的安德鲁·希利尔博士的 研究的方向是发展一类自适应 其结合特性响应于其结合特性的变化的材料。 当地环境。这些材料特别有吸引力， 化学分离由于其环境敏感性可用作 分析物结合的信号或作为主动 控制化学亲和力。 具体来说，一系列 超分子化合物将基于以下大环构建： 阳离子选择性聚醚和阴离子选择性聚铵， 与氧化还原活性的二烯或光响应性的 重氮苯。 大环化合物的化学亲和性将被调整 通过改变其化学成分和环的大小来调节 选择性小，无机离子范围从卤化物， 过渡金属光电化学诱导的 这些材料中结合行为的转换将是 研究了这些大分子的分离特性 将在水溶液中进行检查，同时掺入液体中 和双层脂质膜。 这项工作提供了一类新型的材料， 化学结合行为和转换机制， 外部触发以主动控制基于膜的分离 工艺和设计新的化学传感技术。这项工作将 导致新材料的发现和应用， 一个专门控制的局部环境， 化学亲和性和运输性能。

Author: vjohn at nsf18 Date: 7/8/98 9:19 AM Priority: Normal TO: adthomas Subject: 9815482 Hillier - Abstract ------------------------------- Message Contents ------------------------------- Abstract Proposal No: 9815482 Proposal Type: SGER Principal Investigator: Andrew Hillier Affiliation: University of Virginia This grant is awarded through the Separations and Purification Program sub-element of the Interfacial, Transport and Separations Program of the Chemical and Transport Systems Division. The principal investigator is Dr. Andrew Hillier at the University of Virginia. The research is directed towards the development of a class of adaptive materials whose binding characteristics respond to changes in their local environment. These materials are particularly attractive in chemical separation as their environmental sensitivity can be used as either a signal of analyte binding or as a means of actively controlling chemical affinity. Specifically, a series of supramolecular compounds will be constructed based on macrocylces of cation-selective polyethers and anion-selective polyammoniums that are tethered to redox-active metallocenes or optically-responsive diazobenzenes. The chemical affinity of the macrocycle will be tuned by varying its chemical composition and ring size to adjust selectivity for small, inorganic ions ranging from halides to transition metals. The impact of optically electrochemically-induced switching of the binding behavior in these materials will be investigated. The separation characteristics of these macromolecules will be examined in aqueous solutions while incorporated into liquid and bilayer lipid membranes. This work provides a novel class of materials with highly controllable chemical binding behavior and a switching mechanism that can be externally triggered to actively control membrane-based separation processes and design novel chemical sensing techniques. The work will lead to the discovery and implementation of new materials that provide a specifically controlled local environment for manipulation of chemical affinity and transport properties.